奈达铂联合氟尿嘧啶治疗晚期鼻咽癌的临床观察

Clinical Observation of Nedaplatin Combined with Fluorouracil in the Treatment of Advanced Nasopharyngeal Carcinoma

目的:观察奈达铂(NDP)联合氟尿嘧啶(5-FU)治疗晚期鼻咽癌的近期疗效和安全性。方法:将我院2005年-2011年42例晚期鼻咽癌患者随机均分为治疗组和对照组,治疗组采用NDP80～100mg·m-2,静脉滴注,d1;5-FU600mg·m-2,d1～5。对照组采用顺铂(CDDP)30mg·m-2,静脉滴注,d1～3;5-FU600mg·m-2,d1～5。2组均3周为1个周期,治疗2个周期后评价近期疗效及不良反应。结果:治疗组与对照组的有效率分别为61.90%和38.10%,治疗组明显优于对照组,差异有统计学意义(P<0.05)。与对照组比较,治疗组消化道不良反应、肝肾毒性轻微,差异有统计学意义(P<0.05)。结论:NDP联合5-FU治疗晚期鼻咽癌近期疗效及安全性较好。

OBJECTIVE： To observe short-term efficacy and safety of nedaplatin （NDP） combined with fluorouracil （5-FU） in the treatment of advanced nasopharyngeal carcinoma. METHODS： 42 cases of advanced nasopharyngeal carcinoma were randomly divided into treatment group and control groups equally in our hospital from 2005 to 2011. Treatment group was given NDP 80～100 mg·m^-2, iv. gtt., d1; 5-FU 600 mg·m^-2, d1～5. Control group was given CDDP 30 mg·m^-2,iv.gtt., d1～3,5-FU 600 mg·m^-2,d1～5. A treatment course lasted for 3 weeks. After 2 periods, short-term efficacy and adverse drug reaction were evaluated. RESULTS： The total effective rates of 2 groups were 61.90% and 38.10%, there was statistical significance （P〈0.05）. ADR of digestive tract and liver and kidney toxicity in treatment group was lighter than control group, there was statistical significance （P〈0.05）. CONCLUSION： The short-term efficacy and safety of NDP combined with 5-FU have sound short-term efficacy and safety in the treatment of advanced nasopharyngeal carcinoma.