硫辛酸联合尼莫地平治疗老年糖尿病周围神经病变的临床观察

Clinical Observation of Lipoic Acid Combined with Nimodipine in Elderly Patient with Diabetic Peripheral Neuropathy

目的:观察硫辛酸联合尼莫地平治疗老年糖尿病周围神经病变的临床效果。方法:将78例老年糖尿病周围神经病变患者随机均分为2组。治疗组给予硫辛酸600mg,静脉滴注,qd;尼莫地平40mg,口服,tid。对照组给予尼莫地平40mg,口服,tid。2组均连续治疗3周。观察2组治疗前、后临床症状和神经传导速度的变化。结果:治疗后,2组临床症状、神经传导速度明显改善。与对照组比较,治疗组改善更加明显(P<0.05)。2组均未见严重不良反应发生。结论:硫辛酸联合尼莫地平治疗老年糖尿病周围神经病变,疗效显著,安全性较好。

OBJECTIVE： To observe the effect of lipoic acid combined with nimodipine in elderly patient with diabetic peripheral neuropathy. METHODS： 78 elderly patients with diabetic peripheral neuropathy were randomly divided into 2 groups. The therapy group （39 cases） which were treated with lipoic acid 600 mg intravenously once a day and nimodipine 40 mg orally, tid; The control group （39 cases） given nimodipine 40 mg orally, tid. 2 groups of continuous treatment were 3 weeks. Clinical symptoms and nerve conduction velocity were examined before and after treatment. RESULTS： After treatment, 2 groups of patients with diabetic peripheral neuropathy symptoms and signs, nerve conduction velocity improved significantly. Compared with the control group, treatment group improved more significantly （P〈0.05）. There were no serious ADRs found in 2 groups. CONCLUSION： The combined use of lipoic acid and nimodipine treatment may improve the elderly diabetic peripheral neuropathy.