抗氧化治疗对糖尿病肾脏病患者肾功能的保护作用

Protective effect of antioxidative therapy with vitamin E and vitamin C on renal function in diabetic nephropathy patients

目的探讨维生素E联合维生素C抗氧化治疗对2型糖尿病肾脏病患者肾功能的保护作用。方法选择我院2型糖尿病肾脏病患者80例，随机分为2组，对照组（A组）接受常规治疗；抗氧化治疗组（B组）除常规治疗外，口服维生素E（0．1g／次，每日1次）、维生素C（0．2g／次，每日3次）。每3个月随访1次，观察记录患者的肾功能，以血肌酐（SCr）升高1倍为随访终点，SCr升高1倍所经历的时间为肾功能生存时间，最长随访时间为2年。结果A组肾功能平均生存时间为（14．78±0．64）个月；B组平均生存时间为（18．16±0．68）个月，2组比较有统计学差异（P〈0．05）。结论维生素E联合维生素c抗氧化治疗对糖尿病肾脏病患者肾功能具有保护作用。

Objective To investigate the protective effect of antioxidative therapy with vitamin E and vitamin C on renal function in patients with diabetic nephropathy （DN）. Methods An prospective randomized controlled trial was performed to investigate the protective effect of antioxidative ther-apy in patients with type 2 diabetic nephropathy. A total of 80 DN patients were recruited in Air Force General Hospital. These patients were randomly divided into two groups： control group （goup A） and trial group （group B）. Each group had 40 patients respectively. The patients in group A received usual treatment, and those in group B received antioxidative agents besides usual treatment. The antioxidative agents were vitamin E （0. 1 g/time, per os, 1 time/day） and vitamin C （0. 2 g/time, per os, 3 times/day）. At scheduled visits of every three months all patients underwent examination of serum ereatinine （SCr）. The follow-up endpoint was the day when Ser was increased by one fold. The survival time of renal function was defined as the time from the start to the endpoint of follow-up. The longest follow-up period was 2 years. Results The mean survival time of renal function in group B was longer than that in group A （18. 16±0. 68） vs （14. 78±0. 64） months, log-rank P〈0. 05）. Condusions The antioxidative therapy in combination with vitamin E and vitamin C has protective effect on renal function in diabetic nephropathy patients.