摘要
目的探讨维生素E联合维生素C抗氧化治疗对2型糖尿病肾脏病患者肾功能的保护作用。方法选择我院2型糖尿病肾脏病患者80例,随机分为2组,对照组(A组)接受常规治疗;抗氧化治疗组(B组)除常规治疗外,口服维生素E(0.1g/次,每日1次)、维生素C(0.2g/次,每日3次)。每3个月随访1次,观察记录患者的肾功能,以血肌酐(SCr)升高1倍为随访终点,SCr升高1倍所经历的时间为肾功能生存时间,最长随访时间为2年。结果A组肾功能平均生存时间为(14.78±0.64)个月;B组平均生存时间为(18.16±0.68)个月,2组比较有统计学差异(P〈0.05)。结论维生素E联合维生素c抗氧化治疗对糖尿病肾脏病患者肾功能具有保护作用。
Objective To investigate the protective effect of antioxidative therapy with vitamin E and vitamin C on renal function in patients with diabetic nephropathy (DN). Methods An prospective randomized controlled trial was performed to investigate the protective effect of antioxidative ther-apy in patients with type 2 diabetic nephropathy. A total of 80 DN patients were recruited in Air Force General Hospital. These patients were randomly divided into two groups: control group (goup A) and trial group (group B). Each group had 40 patients respectively. The patients in group A received usual treatment, and those in group B received antioxidative agents besides usual treatment. The antioxidative agents were vitamin E (0. 1 g/time, per os, 1 time/day) and vitamin C (0. 2 g/time, per os, 3 times/day). At scheduled visits of every three months all patients underwent examination of serum ereatinine (SCr). The follow-up endpoint was the day when Ser was increased by one fold. The survival time of renal function was defined as the time from the start to the endpoint of follow-up. The longest follow-up period was 2 years. Results The mean survival time of renal function in group B was longer than that in group A (18. 16±0. 68) vs (14. 78±0. 64) months, log-rank P〈0. 05). Condusions The antioxidative therapy in combination with vitamin E and vitamin C has protective effect on renal function in diabetic nephropathy patients.
出处
《临床肾脏病杂志》
2011年第10期467-469,共3页
Journal Of Clinical Nephrology