地尔硫中间体α,β-三元环氧腈的合成

Synthesis of the Intermediate of Diltiazem

通过相转移催化成功合成α,β-三元环氧腈,为地尔硫的合成提供了一种重要的中间体,相对于三元环氧酯的合成提高了产率,从而为地尔硫的合成工艺改造提供了一种方法。

An α,β-epoxynitrile was achieved with phase transfer catalysis,and a new synthetic method for diltiazem was reported herein,which increased the yield in comparison with epoxyester.