微波消解ICP-MS法测定某肺癌高发区居民饮食中28种元素

Determination of 28 Elements of Diet Samples in High Incidence Area of Lung Cancer by Microwave Digestion-ICP-MS

采用真空冷冻干燥和硝酸-过氧化氢体系微波消解处理饮食样品,ICP-MS法测定样品中28种元素的含量。在优化仪器工作参数后,以铑(Rh)和铼(Re)双内标对基体影响和信号漂移进行校正,并采用4种国家标准物质验证该方法的准确度和精密度。结果表明,28种元素检出限为0.01～0.40μg/L,加标回收率为82%～114%,国家标准物质测定值与标准值或参考值一致,精密度(RSD)为0.4%～16.9%。用该方法测定60份肺癌高发区居民饮食样品中28种元素含量,结果可为研究微量元素与肺癌的关系和指导合理膳食提供参考。

A method for determining 28 elements of diet samples was developed by using vac- uum freeze-drying microwave digestion-ICP-MS in HNO3-H2O2 solution system. Under the optimized conditions, the double internal standard elements Rh and Re were used to com- pensate for matrix suppression effect and sensitivity drift. 4 kinds of certified reference materials were analyzed by the described method and the measured element values. The analytical results show that the detection limits of the 28 elements are 0.01-0.40 μg/L. The recoveries are 82%--114%. The elements concentrations are accorded with the standard values or the reference values. The relative standard deviations （RSD） are 0. 4%-16. 9%. The contents of 28 elements in 60 diet samples of people in high lung cancer rate area were determined by this method. The data are useful for studying on the relationship between trace elements and lung cancer and giving some rational diet suggestions.