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鸟氨酸脱羧酶抗酶I与多胺代谢 被引量：4

Ornithine decarboxylase antizyme I and polyamine metabolism
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摘要 鸟氨酸脱羧酶抗酶I(ornithine decarboxylase antizyme 1,OAZ1)是调节细胞内多胺含量的重要因子,参与细胞生长与分化、胚胎发育、基因表达调控等重要生理过程,也是抗肿瘤治疗的潜在分子靶点。简要综述鸟氨酸脱羧酶抗酶I在结构与功能,及其调控多胺代谢机制方面的研究进展。 Ornithine decarboxylase antizyme I is an important factor in regulating intracellular polyamine content and involves in cell growth and differentiation,embryonic development,gene expression regulation,and other important physiological processes.It is also a potential molecular target for anti-tumor therapy.This paper reviews the research progress for ornithine decarboxylase antizyme I in the structure,function,and the mechanism for regulating polyamine metabolism.
作者 蔡富强 王艳林
机构地区 三峡大学医学院 三峡大学分子生物学研究所
出处 《生命科学》 CSCD 北大核心 2011年第10期1002-1008,共7页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金面上项目(30772590)
关键词 鸟氨酸脱羧酶抗酶 多胺 代谢调控 肿瘤 ornithine decarboxylase antizyme polyamine metabolism regulation tumor
分类号 Q786 [生物学—分子生物学] R730.231 [医药卫生—肿瘤]
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参考文献60

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同被引文献61

  • 1缪金明,潘瑞彭.多胺代谢与调节[J].生物化学与生物物理进展,1989,16(1):12-15. 被引量：8
  • 2Casero RA, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov, 2007, 6:373-90.
  • 3Casero RA, Woster PM. Recent advances in the development ofpolyamine analogues as antitumor agents. J Med Chem, 2009, 52:4551-73.
  • 4Moinard C, Cynober L, Bandt JP. Polyamines: metabolism and implications in human diseases. Clin Nutr, 2005, 24 (2): 184-97.
  • 5Radford DM, Nakai H, Eddy RL, et al. Two claromosomal locations for human ornithine decarboxylase gene sequences and elevated expression in colorectal neoplasia. Cancer Res, 1990, 50:6146-53.
  • 6Shantz LM, Levi VA. Regulation of ornithine decar- boxylase during oncogenic transformation: mechanisms and therapeutic potential. Amino Acids, 2007, 33(2): 213- 33.
  • 7Mangold U. The antizyme family: polyamines and beyond. IUBMB Life, 2005, 57(10): 671-6.
  • 8Olsen RR, Zetter BR. Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Mol Cancer Res, 2011, 9(10): 1285-93.
  • 9Hoshino Y, Terashima S, Teranishi Y, et al. Ornithine decarboxylase activity as a prognostic marker for colorectal cancer. Fukushima J Med Sei, 2007, 53(1): 1-9.
  • 10Poulin R, Lu L, Ackermann B, et al. Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by α-difluoromethylornithine characterization of sequ- ences at the inhibitor and coenzyme binding sites. J Biol Chem. 1992, 267:150-8.

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二级引证文献10

生命科学
2011年 第10期

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