米非司酮配伍米索前列醇用于绝经妇女取环术的临床研究

Clinical Study on Appliance of Mifepristone and Misoprostol to Ring Extraction in Postmenopausal Women

目的:探讨米非司酮与米索前列醇不同配伍方式用于绝经妇女取环术的效果。方法:选择门诊要求取环的绝经妇女400例,随机分为A、B、C、D四组各100例。均在术前3 d口服米非司酮2次/d,每次25 mg,术前2 h阴道放置米索前列醇A组600μg、B组400μg、C组200μg、D组不放置。比较四组取环成功率、取环时间、术中宫颈扩张情况、腹痛情况、出血情况及不良反应。结果:与D组比较,A、B、C三组取环成功率高,取环时间短,术中宫颈扩张有效率高,腹痛发生率低,出血量少,不良反应发生率低。有显著性差异(P<0.05)。A、B、C三组间无显著性差异(P<0.05)。结论:米非司酮配伍米索前列醇用于绝经妇女取环术可有效扩张宫颈,减轻患者痛苦,明显提高取环成功率。最佳配伍剂量及方法为术前3 d口服米非司酮2次/d,每次25 mg,术前2 h阴道放置米索前列醇200μg。

Objective：To probe into the appliance of mifepristone and misoprostol to ring extraction in postmenopausal women.Methods：400 post-menopausal women demanding ring extraction are selected and randomly divided into four groups marked A,B,C and D,100 cases for each.Three days before surgery,mifepristone is taken twice a day and 25 mg each time.Two hours before surgery,misoprostol is applied to Vagina,600 μg for group A,400 μg group B,200 μg group C,0 μg group D.We compare the success rates,surgery time,intraoperative cervical dilatation,abdominal pain,bleeding and adverse reactions.Results：Compared with group D,the other three groups demonstrate higher success rates,shorter surgery time,more effectiveness in intraoperative cervical dilatation,less abdominal pain,less blood loss,and fewer adverse reactions.A significant difference（P〈0.05） can be seen between,while there is no significant difference（P〈0.05） among the three groups of A,B and C.Conclusions：The application of Mifepristone and misoprostol to ring extraction for post-menopausal women can effectively expand cervix,relieve pain and significantly improve the success rate.Optimum dosage and method is as below： three days before surgery,mifepristone is taken twice a day and 25 mg each time.Two hours before surgery,200 μg of misoprostol is applied to Vagina.