口服米诺环素联合过氧化苯甲酰治疗痤疮疗效观察

Efficacy of combined therapy of oral minocycline and benzoyl peroxide for acne

目的探讨米诺环素联合外用过氧化苯甲酰治疗痤疮的疗效性,分析两者联合用药与单独口服米诺环素在治疗痤疮疗效方面的差异性,从而为痤疮临床治疗提供较好的方案。方法将45名患者随机分为治疗组和对照组,治疗组接受米诺环素联合过氧化苯甲酰治疗,对照组接受米诺环素治疗,对治疗组和对照组不同疗程(用药后2、4、6、8周及1个月)治愈率的比较,作出评价。结果治疗2周、4周后,米诺环素联合过氧化苯甲酰组总有效率明显高于单口服米诺环素组(P<0.05),6周、8周及1个月时两组无明显差异(P>0.05),说明米诺环素联合过氧化苯甲酰组起效快于单口服米诺环素组。结论米诺环素联合过氧化苯甲酰较单独口服米诺环素起效快,明显缩短病程,较快减轻炎症反应,降低愈后遗留瘢痕的可能性。

Objective To explore the curative effect of combined therapy of oral minocycline and benzoyl peroxide for external use for acne,and to analyze the difference in the efficacy of acne treatment between the combined therapy and single oral minocycline treatment group,all these will provide us a better scheme for acne treatment.Methods Totally 45 patients were randomly divided into treatment and contrast groups.The treatment group accepted the therapy of minocycline combined with benzoyl peroxide,while the contrast group were treated with minocycline alone.Then an evaluation was made by comparing the curative ratio at different time point between the two groups.Results The total effective rate of the group treated with minocycline combined with benzoyl peroxide was significantly higher than that of single oral minocycline group at 2 weeks and 4 weeks after treatment,while the values at different time of 6 weeks,8 weeks and 1 month after treatment had no significant difference between two groups.It showed that treatment with oral minocycline and benzoyl peroxide for external use works faster than therapy with single oral minocycline.Conclusions Combined therapy of oral minocycline and benzoyl peroxide for external use works faster than therapy of single oral minocycline,and it shortens the course of disease,alleviates the inflammatory reaction rapidly,also reduce the possibility of healing scars.