舒洛地特对老年高血压肾损害患者肾功能的影响

Effects of sulodexide on renal function in senile hypertensive patients

目的研究舒洛地特对老年高血压肾损害患者肾功能的保护作用。方法将90例老年高血压肾损害患者随机分为常规治疗组、缬沙坦组和舒洛地特组,均n=30,在分别给予基础治疗同时,用药2组分别服用缬沙坦80 mg.d-1和舒洛地特250 LSU.d-1,观察3 mo。检测治疗前后收缩压、舒张压、肾功能、血清光抑素C(cystatin C)、丙氨酸转氨酶、天冬氨酸转氨酶、空腹血糖、三酰甘油、总胆固醇以及24 h尿蛋白定量、尿β2-微球蛋白(β2-MG)、α1微球蛋白(α1-MG)和尿N-乙酰-β-D葡萄糖苷酶。结果 3组患者治疗前后血压均无明显变化。常规治疗组治疗后各指标均无显著变化(P>0.05);缬沙坦组和舒洛地特组治疗后尿素氮、肌酐和尿酸无显著变化(P>0.05),而24 h尿蛋白、尿α1-MG、β2-MG和NAG均显著减少(P<0.01);舒洛地特组血cystatin C明显减少(P<0.01),与缬沙坦组比较,舒洛地特组各指标减少更加显著(P<0.05或P<0.01)。结论舒洛地特可降低老年高血压肾损害患者的尿蛋白,对肾脏具有良好的保护作用。

AIM To observe the effects of sulodexide on renal function in senile hypertensive patients. METHODS Ninety senile hypertensive patients were randomly allocated into control group （n = 30）, valsartan group （n = 30,80 mg-d-1） and sulodexide group （n = 30,250 LSU.d-1）. All groups were given basic treatment and observed for 3 months Systolic blood pressure （SBP）, diastolic blood pressure （DBP）, serum creatinine （Scr）, blood urea nitrogen （Bun）, uric acid （UA）, cystatin C, alanine aminotransferase （ALT）, aspartate transa- minase （AST）, fasting plasma glucose （FPG）, triglycerides （TG）, total cholesterol （TC）, 24 h urinary protein, urine β2-microglobulin （β2-MG）, α1-microglobulin （α1-MG） and N-β-acetyglocosamidase （NAG） were tested before and after treatment. RESULTS There were no significant difference in SBP and DBP before and after the treatment in three groups （P 〉 0.05）. There were no significant difference in Scr, Bun, UA, cystatin C, 24 h urinary protein, urine β2-MG, α1-MG and NAG before and after the treatment in the control group （P 〉 0.05）. In the valsartan group and the sulodexide group, there were no significant difference in Scr, Bun and UA before and after the treatment （P 〉 0.05）, but 24 h urinary protein, urine β2-MG, α1-MG and NAG decreased significantly （P 〈 0.01 ）. And in the sulodexide group, cystatin C decreased significantly （P 〈 0.01 ）. Compare with the valsartan group, the dec-reases of cystatin C, 24 h urinary protein, urine β2-MG, α1-MG and NAG in the sulodexide group were significant （P 〈 0.05 or P 〈 0.01）. CONCLUSION Sulodexide could improve renal function in senile hypertensive patients.