胱抑素C与糖化血红蛋白联合检测在糖尿病肾病早期诊断中的临床价值

Clinical value of serum cystatin C and glycosylated hemoglobin in early diagnosis of diabetic nephropathy

目的探讨2型糖尿病（T2DM）患者血清胱抑素C（CysC）与糖化血红蛋白（HbAlC）水平对诊断糖尿病早期肾损害的价值。方法将80例T2DM患者根据其肾功能分为肾功能正常组和肾功能异常组，各40例，同时选择40例健康者为对照组。比较各组血清胱抑素C与糖化血红蛋白水平。结果T2DM患者CysC与HbAlc水平均高于对照组（P〈0．05），肾功能异常组患者的CysC与HbAlc水平也明显高于肾功能正常组（P〈0．05）；在T2DM患者中，CysC与HbAIc呈正相关（r=0．39）。结论CysC与HbAlc作为诊断糖尿病早期肾损害的敏感指标，联合检测更具临床价值。

Objective To evaluate the clinical value of the levels of serum cystatin C （CysC）and hemoglobin A1 e （HbAlc）protein in diagnosis of type 2 diabetes mellitus（T2DM） patients with early renal injury. Methods According to the renal function indiee（ including ereatinine and blood urea nitro- gen） , 80 patients with T2DM were divided into two groups：the normal renal function group （n = 40） , the abnormal renal function group （ n = 40）. Another 40 health people served as the control group. The levels of serum CysC and HbAle were examined. Results The levels of serum CysC and HbAlc in pa- tients with T2DM were significantly higher than those in the control group （P 〈 0.05 ）, while the levels of serum CysC and HbA1 e in abnormal renal function group was significantly higher than those in the normal renal function group （ P 〈 0. 05 ）. The level of serum CysC was positively correlated with the level of HbAlc （r = 0. 39）in patients with T2DM. Conclusions CysC and HbAle may be used as sensitive indexes for diagnosing early renal injury in type 2 diabetes mellitus. Combined examination can have more practical value.