急性心肌梗死患者抗心磷脂抗体检测的临床意义

Clinical significance of detection of anticardiolipin antibodies in patients with actue myocardial infarction

目的探讨抗心磷脂抗体（ACA）与急性心肌梗死（AMI）的关系。方法用ELISA法对61例健康者和112例缺血性心脏病患者的ACA水平进行检测。结果ACA阳性百分率对照组为1．6％，冠心病组为36．2％，急性心肌梗死组为87．0％；21例ACA阳性的冠心病患者有6例分别于6～24个月发生AMI，ACA阴性的29例患者无AMI发生；54例AMI患者中，年龄在30～42岁的8例患者ACA全部为阳性。结论部分缺血性心脏病患者的发病可能与ACA阳性有关，尤以AMI相关性明显，对冠心病是否会发生急性心肌梗死，ACA可能有预测价值。

Objective To observe the correlation of anticardiolipin antibody （AGA） and acute myocardial infarction. Methods ELISA was used to detect the ACA levels in 56 healthy people and 106 patients with ischemic heart diseases. Results The positive rate of ACA was 1.6% in control group, 36.2% in coronary heart disease group and 87.0% in acute myocardial infarction group. The acute myo- cardial infarction occurred in 6 of 21 patients with coronary heart diseases with positive ACA within 6 to 24 months, but the acute myocardial infarction didn＇ t occur in coronary heart diseases patients with neg- ative ACA. Among the 56 cases of patients with acute myocardial infarction, 8 cases aged between 30 and 42 had positive ACA. Conclusions Positive ACA probably correlates with the occurrence of ische- mic heart diseases, especially in acute myocardial infarction. ACA can also predict the occurrence of a- cute myocardial infarction in those with coronary heart disease.