IL-15、IL-18的生物活性及其抗肿瘤机制的研究
摘要
普遍认为,肿瘤患者体内存在免疫耐受或免疫抑制,特异杀伤肿瘤细胞的NK细胞和CTL细胞数量减少,同时能激活杀伤肿瘤细胞的细胞因子,
出处
《医学新知》
CAS
2011年第5期372-377,共6页
New Medicine
参考文献40
-
1Megan A,Cooper,Jennifer E B ,et al, In vivo evidence for a depend- ence on interleukin 15 for survival of natural killer cells[ J]. Blood, 2002,100(10) :3633-3638.
-
2Chan C L,Bice P,John D E Y. The emerging role of IL - 15 in NK cell development [ J ]. Immunol Today,2000,21 (3) : 113-116.
-
3Ranson T, Vosshenrich C A, Corcuff E, et al. IL - 15 is all essential mediator of peripheral NK - cell homeostasis [ J 1. Blood, 2003,101 (12) :4887-4893.
-
4Fehniger T A, Shah M H ,Turner M .l,et al. Differential cytokine and chemokine gene expression by human NK cells following activation with IL - 18 or IL - 15 in combination with IL - 12:implications fur the innate immuneresponse [ J ]. Immunol, 1999, 162 ( 8 ) : 4511- 4520.
-
5Grabstein K H, Eisenman J, shannebeck k, et al. cloning of cell growth factor that interacts with the B chain of the interleukin - 2 re- ceptor [ J I. Science, 1994,264:965-968.
-
6Okamura H, Nagata K, Komatsu T, et al. A novel costimulatory factor for Gamma interferon induction found in the livers of mice causes en- dotoxic shock [ J ]. Infect Immun, 1995,63 (10) :3966-3972.
-
7Anderson D M, Johnson L, Glaccum M B, et al. Chromosomal assign- ment andgenomic structure of IL - 15 [ J]. Genomics, 1995,25:701- 706.
-
8Krause H ,jandrig B, Wernickev C, et al. Genomic structure and chro- mosomal localization of the human interleukin 15 gene ( IL - 15 ) [ J 1. Cytokine, 1996,8 : 667 -674.
-
9Tagaya Y, Bamford R N, DeflLippis A P, et al. IL - 15 : A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels [ J ]. Immunity, 1996,4,329 -336.
-
10Kirman I,Nielsen O H, Increase numbers of interleukin - 15 -ex- pressing cells in active ulcerative colitis [ J]. Am J Gastroenterol, 1996,91 : 1789-1794.
-
1杜晓敏,周益民.分析CpG ODN佐剂对呼吸道合胞病毒重组疫苗诱导的细胞免疫应答的作用[J].生物技术世界,2014,11(6):71-71.
-
2靳更林,韩梅,陈东海,寿成超.抗胃癌免疫毒素表达质粒的构建、表达及对肿瘤细胞的特异杀伤[J].中国生物化学与分子生物学报,2000,16(1):57-61.
-
3李娜,曲春枫,吕娥,苗乃法,吴国庆.IL-12基因转染B细胞的抗原提呈功能研究[J].潍坊医学院学报,2007,29(6):493-495.
-
4郭建成.热休克蛋白-肽复合物肿瘤疫苗[J].国外医学(肿瘤学分册),1996,23(5):267-270. 被引量:6
-
5李新燕,张学光.人νδT细胞细胞毒活性研究[J].中国肿瘤生物治疗杂志,1995,2(4):341-342.
-
6陈丹,邹建炫,宗云辉,孟会敏,安刚力,杨林.抗人CD138单克隆抗体以及重组双特异性抗体的开发及应用[J].免疫学杂志,2015,31(1):7-11. 被引量:2
-
7岳瑛,岳玉环,于晓伟,冯书章,朱平,李荷莲,乐杰.重组志贺毒素的表达及活性的初步测定[J].中国病理生理杂志,2003,19(10):1361-1364.
-
8王海凤,郭兵,钟秀会,宫新城.妊娠子宫NK细胞研究进展[J].中国免疫学杂志,2008,24(10):960-960. 被引量:4
-
9才志刚,段德溥,吴胜勇,肖海波.树突状细胞诱导肺癌特异性免疫应答治疗裸鼠移植瘤的实验研究[J].北京医学,2007,29(1):35-38. 被引量:2
-
10CD4^+T细胞肿瘤研究取得进展[J].上海交通大学学报(医学版),2007,27(4):423-423.