乌体林斯联合布地奈德防治毛细支气管炎后哮喘的临床观察

Utilin′s combined with Budesonide in the prevention and treatment of asthma following bronchiolitis

目的:观察应用乌体林斯联合布地奈德降低毛细支气管炎后哮喘发病率,寻找更好的治疗和预防小儿毛细支气管炎发展成哮喘的方法。方法:61例确诊毛细支气管炎的患儿随机分成防治组(n=31)和对照组(n=30),两组均吸入布地奈德气雾剂100μg/次,2次/d,2个月后减量至100μg/(次.d),维持1个月后停药。防治组加乌体林斯肌内注射1.72μg/次,1次/周,共用10次,临床随访1年,观察1年内每组哮喘的发生率。结果:防治组与对照组的哮喘发生率差异有统计学意义(P<0.05)。结论:应用乌体林斯联合布地奈德可明显降低毛细支气管炎后哮喘的发病率。

Objective To observe the effects of Utilin′s combined with Budesonide decreasing the incidence of asthma following bronchiolitis and find a better way of curing and preventing bronchiolitis developing into asthma.Method Total 61 cases with bronchiolitis were randomly divided into two groups：the treatment group（n=31）and the control group（n=30）.Budesonide Aerosol was inhaled by all cases（100 μg every time and two times everyday）.Two months later,Budesonide Aerosol was inhaled 100 μg everyday and a month later withdrawal.Besides in the treatment group 1.72 μg Utilin′s was injected every time and 1 time/week,in total ten times.The cases were followed for a year and the incidence of asthma was oberved.Results The incidence of asthma was significantly lower in the treatment group than that of the control group（P0.05）.Conclusion Utilin′s combined with Budesonide can obviously decrease the incidence of asthma following bronchiolitis.