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血清胱抑素C在2型糖尿病肾功能损伤早期诊断中的价值 被引量:11

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摘要 目的探讨2型糖尿病肾功能损伤患者血清胱抑素C(CysC)变化的临床意义。方法检测98例2型糖尿病患者血清CysC、肌酐(Cr)及β2-微球蛋白(β2-MG)变化,分析其与肾小球滤过率(GFR)的相关性。结果 Cy-sC、Cr及β2-MG均随GFR下降逐渐升高,与GFR均呈负相关(P<0.01),CysC与GFR的相关性强于Cr及β2-MG。ROC曲线分析显示CysC曲线下面积(AUC)较大,诊断2型糖尿病肾功能损伤的敏感性及特异性、特异性、敏感性及精确性均明显高于Cr及β2-MG。结论 CysC是早期诊断2型糖尿病肾功能损伤的敏感指标。
机构地区 锦州市中心医院
出处 《山东医药》 CAS 北大核心 2011年第39期44-45,共2页 Shandong Medical Journal
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参考文献10

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二级参考文献4

  • 1Grubb A.Diagnostic value of analysis of cystatin C and protein HC in biological fluids.Clin Nephro,1992,38[suppl 1]:20-27
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