乳腺癌分子靶点药物作用途径研究进展
摘要
乳腺癌是一种复杂的疾病,化疗、手术、放疗及药物治疗是其主要治疗方法。研究证实,三苯氧胺长期服用会增加子宫内膜癌的风险,而赫塞汀被证实有严重的心脏毒性;因此发展新型高效低毒的分子靶向药物成为提高患者生存质量的必要手段。近年分子靶点药物及其作用途径的研究取得了一定进展，现概述如下。
出处
《山东医药》
CAS
北大核心
2011年第39期115-116,共2页
Shandong Medical Journal
参考文献16
-
1Moulder S, Hortobagyi GN. Advances in the treatment of breast cancer[J]. Clin Pharmacol Ther, 2008,83( 1 ) :26-36.
-
2Van der Auwera, Van Laere SJ, Van den Eynden GG, et al. increased angiogenesis and lymph-angiogenesis in inflammatory versus non-inflammatory breast cancer by real-time reverse transcriptase- PCr gene expression quantification[ J]. Clin Cancer Res, 2004,10 (23) :7965-7971.
-
3Achen MG, Mann GB, Seacher SA, et al. Targeting lymphangio-genesis to prevent tumour metastasis [ J]. Br J Cancer, 2006,94 (10) :1355-1360.
-
4shirakawa K, Wakasugi H, Heike Y, et al. vasculogenic mimicry and pseudo-comedo formation in breast cancer [ J ]. Int J Cancer, 2002,99(6) :821-828.
-
5Hurley J, Doliny P, Reis I, et al. Docetaxel, cisplatin, and trastuzumab as primary systemic therapy for human epidermal growth factor receptor 2-positive locally advanced breast cancer [ J ]. J Clin Oncol, 2006,24(12) : 1831-1838.
-
6Johnston S, Trudeau M, Kaufman B, et al. Phaseii study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 ( Her-2 ) in advanced inflammatory breast cancer with lapatinib monotherapy [ J ]. J Clin Oncol, 2008,26 (7) : 1066-1072.
-
7Lev DC, Kim LS, Melnikova V, et al. Dual blockade of eGFr and erK1/2 phosphorylation potentiates growth inhibition of breast cancer cells[J]. Br J Cancer, 2004,91 (4) :795-802.
-
8Van Golen KL, Davies S, Wu ZF, et al. A novel putative low-affinity insulin-like growth factor-binding protein, LiBC ( lost in inflammatory breast cancer), and rhoC GTPase correlate with the inflammatory breast cancer phenotype [ J ]. Clin Cancer Res, 1999,5 (9) : 2511-2519.
-
9Hwa V, Oh Y, Rosenfeld RG, et al. The insulin-like growth factorbinding protein (iGFBP) superfamily[ J]. Endocr Rev, 1999,20 (6) :761-787.
-
10Kleer CG, Zhang Y, Pan Q, et al. WisP3 is a novel tumor suppressor gene of inflammatory breast cancer[ J ]. O ncogene, 2002,21 (20) :3172-3180.
-
1胡艳萍.非小细胞肺癌化疗进展[J].肿瘤防治研究,2006,33(7):545-548. 被引量：4
-
2葛敏.非小细胞肺癌化疗进展[J].右江民族医学院学报,2008,30(6):1072-1074. 被引量：1
-
3王振兴.非小细胞肺癌的治疗[J].医学综述,2007,13(9):690-692. 被引量：5
-
4赵勇,傅羽,吴耀华,刘晓岭,陈杨,张志强.参芪扶正注射液与赫塞汀联合应用对乳腺癌细胞增殖和凋亡的影响[J].哈尔滨医科大学学报,2013,47(3):232-235. 被引量：10
-
5何向明,李苏宜.分子靶点药物治疗食管癌的临床研究进展[J].中国肿瘤,2009,18(4):299-303. 被引量：8
-
6李冬,赵锋,佟丹.原发性肝细胞癌的CT诊断与鉴别诊断[J].吉林医学,1998,19(6):323-324.
-
7姜宝飞,葛恒发,于仁,张建淮,朱晋国,陶国全,刘斌.胃肠道间质瘤65例诊治分析[J].中国误诊学杂志,2010,10(22):5458-5459.
-
8钟连花,刘健,陈俊强.食管癌术后辅助放化疗的临床研究[J].中国医药导报,2010,7(7):11-12.
-
9莫秀瑛,李力,肖晓兰,李菲,黄薇,张洁清,姚德生.影响卵巢上皮性癌化疗疗效的临床病理因素分析[J].实用妇产科杂志,2008,24(10):605-609. 被引量：1
-
10付荣明.直肠间质瘤12例诊治分析[J].江西医药,2008,43(11):1173-1174.
