摘要
目的:通过对IL-6、TNF-α及CRP的检测,探讨蛭龙活血通瘀胶囊对大鼠肾性高血压血压的保护机制。方法:将实验动物分为6组:正常对照组、模型组、假手术组、蛭龙活血通瘀胶囊大剂量组、蛭龙活血通瘀胶囊中剂量组、蛭龙活血通瘀胶囊小剂量组,建立肾性高血压模型,给予不同的药物治疗,8周后行IL-6、TNF-α及CRP的检测。结果:模型组大鼠血清CRP、IL-6及TNF-α较正常组、假手术组明显升高(P<0.05),假手术组大鼠血清CRP、IL-6及TNF-α与正常组比较无明显差异(P>0.05),治疗后高剂量组、中剂量组和低剂量组大鼠血清CRP、IL-6及TNF-α与模型组比较,高、中剂量组明显降低(P<0.05),高剂量组与低剂量组之间比较降低有统计学意义(P<0.05),但高剂量组与中剂量组之间比较无统计学意义(P>0.05)。结论:蛭龙活血通瘀胶囊能降低IL-6、TNF-α及CRP水平,具有一定的抗炎作用和免疫调节作用。
Objective:Through the test of IL-6,TNF-α and CRP,to probe into the protection mechanisms of Zhilong Huoxue Tongyu Capsule on blood pressure of renal hypertensive rats.Methods: The experimental animals were divided into six groups: normal control group,model group,sham operation group,Zhilong Huoxue Tongyu Capsule groups(high dose group,middle dose group and low dose group).The renal hypertension models were established and given different medication,and IL-6,TNF-α and CRP were tested 8 weeks after the treatment.Results: Serum CRP,IL-6 and TNF-α of model group were significantly increased(P0.05)compared with those of normal group and sham group,and there were no significant difference(P 0.05) between normal group and sham group in serum CRP,IL-6 and TNF-α.After the treatment,serum CRP,IL-6 and TNF-α of high-dose group,middle dose group and low dose group were significantly decreased(P 0.05) compared with those of model group.There was statistical significance between the high-dose group and low dose group(P0.05),while there was no significant difference between the high-dose group and low dose group(P0.05).Conclusion: Zhilong Huoxue Tongyu Capsule can reduce levels of IL-6,TNF-α and CRP,with some anti-inflammatory and immunomodulatory effects.
出处
《河南中医》
2011年第11期1239-1241,共3页
Henan Traditional Chinese Medicine
基金
四川省教育厅自然科学青年基金科研项目(编号:川教函[2008]30号)