炎症相关性指标在评价强直性脊柱炎活动性中的价值

Significance of inflammation indexes in disease activity assessment of ankylosing spondylitis

目的探讨强直性脊柱炎(ankylosing spondylitis,AS)患者各炎症相关性指标与疾病活动性的相关性。方法依据Bath强直性脊柱炎活动性指标(BASDAI)将60例AS患者分为36例活动组和24例静止组,比较2组AS患者的各项实验室指标,并与30例健康对照者做对比。结果活动组AS患者ESR、CRP、IgA、IgG明显高于与静止组和正常对照组(P<0.01),而WBC、PLT、IgM、C3、C4无统计学差异(P>0.05);ESR、CRP、IgA与BASDAI存在正相关(P<0.01);IgA与ESR、CRP存在正相关(P<0.01)。结论除了ESR和CRP外,IgA也可作为反映AS疾病活动性的一项实验室指标。

We aim to explore the correlation between inflammation indexes with disease activity in ankylosing spondylitis （AS） patients. According to the BASDAI index, 60 AS patients were divided into activity group and static group, then we compared the laboratory parameters among active group, static group, and normal group. The results showed that the ESR, CRP, IgA and IgG levels in activity group were significantly higher than that in static group or normal group （P 〈 0.01）, but the WBC, PLT, IgM, C3, C4 level showed no significant difference in the 3 groups （P 〉 0.05）. Furthermore, The ESR, CRP, IgA levels were positively correlation with the BASDAI index （P 〈 0.01）, and the IgA was positively correlated with ESR and CRP （P 〈 0.01）. The data imply that besides the ESR and CRP, The IgA can also be a laboratory parameter to assess AS disease activity.