摘要
目的探讨苦杏仁水煎剂在治疗佐剂性关节炎(AA)大鼠中的抗炎作用机制。方法建立佐剂性AA大鼠模型,观察苦杏仁水煎剂对AA大鼠足肿胀、关节组织病理变化及血清中促炎细胞因子TNF-α与sICAM-1水平的影响。结果苦杏仁水煎剂高剂量组能有效抑制佐剂性AA大鼠关节肿胀及减轻组织炎症的发展,降低佐剂性关节炎大鼠血清中促炎细胞因子TNF-α及sICAM-1的水平。结论苦杏仁水煎剂对佐剂性关节炎大鼠具有良好的抗RA作用,其作用与抑制促炎细胞因子TNF-α及sICAM-1的水平有关。
Objective It is to approach the antiinflammatory mechanism of Apricot Kernel in treating rat with adjuvanticity arthritis（AA）. Methods AA rat model was established.The influences of Apricot Kernel for ankle swelling,pathology of anklebone and the concentration of TNF-α and sICAM-1 were observed after medication. Results High dose Apricot Kernel could effectively inhibit articular swelling,decrease inflammatory in tissue of AA rats and pull down the levels of TNF-α and sICAM-1. Conclusion Apricot Kernel has antiarthritic effects to AA rat model,which may be associated with the levels of TNF-α and sICAM-1.
出处
《现代中西医结合杂志》
CAS
2011年第33期4198-4199,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
新疆医科大学大学生创新课题(CX2009002)
