期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

睾丸性不育症中Bim蛋白的表达 被引量：1

Expression of Bim proteins in testicular infertility
下载PDF
导出
摘要 目的研究正常睾丸组织和睾丸性不育症组织中Bim蛋白的表达,探讨其与睾丸性不育症的关系。方法应用免疫组化SP法对10例正常睾丸组织和50例睾丸性不育症组织中生精细胞Bim蛋白的表达进行检测。结果生精细胞Bim蛋白的阳性表达率在睾丸性不育症中明显高于正常睾丸组织,差异具有统计学意义(P<0.05),与生精障碍程度相关(P<0.05)。结论 Bim可能在睾丸性不育症的发生和发展中起作用。检测Bim表达水平,可以为临床评估和处理睾丸性不育症提供参考依据。 Objective To investigate the expression of Bim proteins in spermatogenic cell of testicular infertility, and to study the relationship between Bim proteins and testicular infertility. Methods The expression of Bim proteins was detected by immunohistochemical staining SP method in 10 cases of normal testicular tissue and 50 cases of testicular infertility. Results The positive rate of Bim protein was significantly higher in the spermatogenic cell of testicular infertility than in normal testicular tissue （P0.05）. Bim protein was found to be related with the degree of spermatogenesis impairment （P0.05）.Conclusion Bim may play certain roles in the occurrence and development of testicular infertility. The detection of Bim expression levels provides a reference for the clinical assessment and treatment of testicular infertility.
作者 成克伦 李廷超 箭华勇 马明宗
机构地区 遵义医学院第三附属医院病理科
出处 《海南医学》 CAS 2011年第22期7-8,共2页 Hainan Medical Journal
关键词 睾丸性不育症 生精细胞 BIM 免疫组化 Testicular infertility Spermatogenic cell Bim Immunohistochemistry
分类号 R698.2 [医药卫生—泌尿科学]
  • 相关文献

参考文献8

  • 1吴刚,伦玉兰.中国优生学[M].北京:科学技术文献出版社,2000:892.
  • 2Strasser A, Puthalakath H, Bouillet P, et al. The role of bim, a pro- apoptotic BH3-onlymember of the Bcl-2 family in cell-death con- trol [J]. Ann N YAcad Sci, 2000, 917: 541-548.
  • 3边睿,陈佺,朱大海.Bim介导细胞凋亡的调控及临床意义[J].国际遗传学杂志,2006,29(5):379-383. 被引量：6
  • 4Marani M, Tenev T, Hancock D, et al. Identification of novel iso- forms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis [J]. Mol Cell Biol, 2002, 22(11): 3577-3589.
  • 5O'reilly LA, Cullen L, Visvader J, et al. The proapoptotic BH3 -- only protein Bim is expressed in hematopoietic, epithelial, neuro- nal, and germ cells [J]. Am J Path, 2000, 157(2): 449-461.
  • 6Szegezdi E, Herbert KR, Kavanagh ET, et al. Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mito-chon- drion via regulation of Bim [J]. J Cell Mol Med, 2008, 12(6A): 2482-2496.
  • 7叶艳,张林杰.凋亡调节蛋白BIM的研究进展[J].国外医学（生理病理科学与临床分册）,2004,24(6):548-550. 被引量：4
  • 8龚传明,屈磊,胡海涛,章涛.非小细胞肺癌Bim和Caspase-3蛋白表达检测及临床意义[J].临床军医杂志,2010,38(2):256-258. 被引量：6

二级参考文献69

  • 1Huang DCS,Strasser A. BH3-only proteins-essential initiators of apoptotic cell death [ J ]. Cell ,2000,103 ( 6 ) :839-42.
  • 2Zong WX,Lindsten T,Ross AJ,et al. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak [J]. Genes Dev,2001 , 15 ( 12 ): 1481-1486.
  • 3Li P, Nijhawan D, Wang X, et al. Mitochondrial activation of apoptosis[J]. Cell,2004,116(2 suppl) :s57-s59.
  • 4Chen D,Zhou Q. Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling[J]. Proc Natl Acad Sci U S A,2004, 101 (5) :1235-1240.
  • 5Putcha G,Le S,Frank S,et al. JNK-mediated Bim phosphorylation potentiates Bax-dependent apoptosis [ J ]. Neuron, 2003, 38 (6):899-914.
  • 6Gilley J, Coffer P, Ham J. FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons[J]. J Cell Biol,2003, 162(4) :613-622.
  • 7Dijkers PF, Birkenkamp KU, Lam EW,et al. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial i ntergrity [ J ]. J Cell Biol, 2002,156 ( 3 ) :531-542.
  • 8Shinjyo T, Kuribara R, Inukai T, et al. Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signalning in murine hematopoietic progenitors [J]. Mol Cell Biol,2001,21 (3) :854-864.
  • 9Dijkers PF,Medema RH,Lammers JW,et al. Expression of the proapoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHRL1 [ J ]. Curr Biol,2000, 10 (19): 1201 -1204.
  • 10Marani M,Hancock D,Lopes R,et al. Role of Bim in the survival pathway induced by Rafin epithelial cells[J]. Oncogene,2004,23(14) :2431-2441.

共引文献10

同被引文献9

引证文献1

海南医学
2011年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部