摘要
目的探讨尿液α1-微球蛋白测定对糖尿病肾病小管间质病变的诊断价值。方法选取糖尿病肾病患者60例,分为微量蛋白尿组、临床蛋白尿组、肾功能不全组,每组20例,并设正常对照组20例,分别进行血液生化与尿液α1-微球蛋白测定。结果微量蛋白尿组、临床蛋白尿组、肾功能不全组的尿液α1-微球蛋白分别为(23.3±17.6)mg/24h,(41.9±22.8)mg/24h,(73.6±37.1)mg/24h,均高于对照组的(10.6±4.2)mg/24h,P均<0.01。而且尿液α1-微球蛋白与Scr呈正相关,相关系数为0.37,P<0.01。结论尿液α1-微球蛋白检测可用来判断糖尿病肾病的小管间质损害。
Objective To investigate the value of the determination of urinary alpha 1-microglobulin in the diagnosis of tubulointerstitial lesion of human diabetic nepgropathy (DN). Methods Sixty patients with DN were divided into three groups, each with 20 cases: group A (the microproteinuria group, with urinary albumin 30~299 mg/24 h), group B (the clinical proteinuria group, with urinary albumin≥300 mg/24 h and serum creatine115 μmol/L), group C (the dysfunction group, urinary albumin≥300 mg/24 h and serum creatine 115~445 μmol/L). Twenty healthy individuals were enrolled as the control group. The levels of urine albumin, alpha 1-microglobulin and serum creatine were determined in the four groups. Results The levels of alpha 1-microglobulin in group A, group B, group C were (23.3±17.6) mg/24 h, (41.9±22.8) mg/24 h, (73.6±37.1) mg/24 h, respectively, which were significantly higher than that in the control group (P0.01). A positive correlation was found between alpha 1-microglobulin and serum creatine (r=0.37, P0.01). Conclusion Determination of urinary alpha 1-microglobulin is quite valuable for the diagnosis of tubulointerstitial lesion of human diabetic nepgropathy.
出处
《海南医学》
CAS
2011年第22期114-115,共2页
Hainan Medical Journal
基金
上海市卫生局基金项目(编号:2008Y04)
院级课题项目(编号:1086)
关键词
尿液
Α1微球蛋白
小管间质损害
糖尿病肾病
Urine
Alpha 1-microglobulin
Tubulointerstitial lesion
Diabetic nephropathy