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脑胶质瘤患者血清中基质金属蛋白酶-2含量的动态研究 被引量：5

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摘要 目的动态监测脑胶质瘤患者术前及术后不同时期血清中MMP-2的含量,结合同期影像学检查,为临床对脑胶质瘤患者适时选择适当的治疗方案提供依据。方法选取30例经病理证实的脑胶质瘤患者,按kernohan分类法,Ⅰ-Ⅱ级10例,Ⅲ级10例,Ⅳ级10例。检测各分级患者术前,术后3、6、12个月的血清中MMP-2的含量,比较各分级患者术前血清MMP-2含量差异以及术后复发与否患者血清MMP-2含量的变化。结果低级别脑胶质瘤较高级别脑胶质瘤血清中MMP-2的表达明显降低,差异有统计学意义(P<0.001)。术后12个月复查MRI,Ⅳ级患者有7例复发,复发者血清MMP-2表达较未复发有明显升高(P<0.01)。结论血清中MMP-2的含量与脑胶质瘤的恶性程度及复发密切相关。
作者 向晖 刘健民 杨小兰 孙卫 张建中 万登峰 何锦华 梁爱军 冷景兴 周超 古金海
机构地区 江西省人民医院神经外科
出处 《实用临床医学（江西）》 CAS 2011年第8期14-16,共3页 Practical Clinical Medicine
关键词 星形细胞瘤 血清 基质金属蛋白酶-2 临床研究
分类号 R739.41 [医药卫生—肿瘤]
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参考文献10

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共引文献7

同被引文献36

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引证文献5

二级引证文献12

实用临床医学（江西）
2011年 第8期

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