血清降钙素原PCT检测在发热待查病因初筛的临床应用

The clinical application of serum procalcitonin in the differntiation of the cause of fever patients

目的探讨血清降钙素原(PCT)检测在发热待查疾病的鉴别诊断价值。方法对200例因发热收住院患者采用胶体金比色法检测患者血清PCT水平,检测结果 4个等级,正常值<0.5 ng/ml,超过0.5 ng/ml为阳性阈值,>10 ng/ml考虑重度感染。结果在非细菌感染性疾病组中阳性率为10%、其浓度以0.5～2 ng/ml为主;细菌性感染组阳性率为58.6%,以0.5～2、2.0～10.0 ng/ml为主。非细菌感染性疾病组及细菌感染组血清PCT水平差异有统计学意义(P<0.01)。结论非细菌感染性疾病患者血清中PCT水平不升高或轻度升高,而细菌性感染患者及重度感染患者血清中PCT水平则明显升高,尤其以重度感染组患者为甚。

Objective To evaluate the value of serum procalcitonin analysis in the differentiation of the cause of fever patients.Methods 200 cases of hospitalized patients with fever received gold assay for measuring serum PCT levels amd the results were divided into 4 grades.0.5 ng/ml was regarded as the positive threshold value and 10 ng/ml considered severe infection.Results The positive rate of serum procalcitonin in the patients with non-bacterial infection and bacteria infection were 10%,58.6%,respectively.Mainly concentrated in the concentration were 0.5 ng/ml and 0.5~2,2.0~10.0 ng/ml respectively for the two groups of non-bacterial infection and bacteria infection（P0.01）.Conclusion Patients with non-bacterial infection have nomal or slightly elevated serum PCT levels,whereas patients with bacteria infection have significantly elevated,particularly in patients with severe infection.