双水平无创正压通气在重度支气管哮喘患儿中的应用研究

Study of noninvasive Bi-level positive airway pressure ventilation in the treatment of severe bronchial asthma in children

目的探讨双水平无创正压通气在儿童重度支气管哮喘治疗中的临床疗效和价值。方法将60例重度支气管哮喘患儿分成观察组和对照组各30例;两组均给予常规药物治疗,对照组给予鼻导管吸氧,观察组给予双水平无创正压通气。比较两组患儿治疗前和治疗后1 h、4 h的血气分析指标(pH、PaO2、PaCO2、SaO2)的变化。结果治疗后,观察组血气分析指标、PEF值的改善均较对照组明显(P<0.05);观察组症状消失时间和住院时间明显短于对照组(P<0.05)。结论常规治疗结合双水平无创正压通气应用于儿童重度支气管哮喘,可以显著改善患儿的临床症状,减少住院时间。

Objective To explore the clinical effect and value of noninvasive Bi-level positive airway pressure ventilation in the treatment of severe bronchial asthma in children.Methods 60 cases of children with severe bronchial asthma were divided randomly into the intervention group（30 cases） and the control group（30 cases）.Two groups of children were treated with conventional drugs.The intervention group was given noninvasive Bi-level positive airway pressure ventilation and the control group was given mask oxygen-inspiration.The change in arterial blood gas parameters（pH、PaO2、PaCO2、SaO2） and peak expiratory flow（PEF） were studied before and 1 hour and 4 hours after the treatment.The disappearance time of symptoms,physical sign and hospitalizing time were compared between the two groups.Results Comparing with the control group,arterial blood gas parameters and PEF were obviously improved in the intervention group.The disappearance time of symptoms,physical sign and hospitalizing time was shortened in the intervention group after treatment and there were significant differences between the groups（P0.05）.Conclusion Routine therapy combined with noninvasive Bi-level positive airway pressure used in treatment of serious bronchial asthma in children can obviously improve the symptoms,reduce hospital stay time,and hence is worthy of being recommended for a wider use in clinical practice.