654-2联合地塞米松胸腔内注射治疗结核性胸膜炎的临床观察

Clinical study of anisodamine combined with dexamethasone in treatment of tuberculous pleurisy by chest injection

目的观察山莨菪碱(654-2)联合地塞米松胸腔内注射治疗结核性胸膜炎的临床疗效。方法 54例结核性胸膜炎患者分为两组,对照组(27例)为常规口服抗结核药物及胸腔穿刺抽液治疗,治疗组(27例)在对照组治疗基础上,胸腔抽液后注入654-2 20 mg,地塞米松5 mg。两组疗程均为2周。观察两组患者治疗后胸水吸收及胸膜肥厚粘连情况。结果治疗组治疗总有效率(85.2%)明显优于对照组治疗总有效率(70.4%)(P<0.05);治疗组胸膜肥厚粘连发生率(7.4%)也明显低于对照组(18.5%)(P<0.05)。结论 654-2联合地塞米松胸腔内注射治疗结核性胸膜炎可快速消除胸水及减轻胸膜的肥厚粘连情况。

Objective To observe the clinical efficacy of anisodamine combined with dexamethasone in treatment of tuberculous pleurisy by chest injection.Methods Fifty-four cases of tuberculous pleurisy were divided into two groups.The control group（n=27） was treated with conventional oral anti-TB drugs and pleural puncture fluid therapy,while the treatment group（n=27） was treated with pumping the chest after the injection of liquid anisodamine 20 mg,and dexamethasone 5 mg in addition to the treatment in the control group.The treatment duration lasted two weeks for both groups.The situation of pleural effusion,pleural thickening and adhesions absorption were observed after the treatment.Results The total effective rate of the treatment group（85.2%） was significantly better than that of the control group（70.4%）（P0.05）.The incidence of pleural thickening and adhesion of the treatment group（7.4%） was significantly lower than that of the control group（18.5%）（P0.05）.Conclusion Anisodamine combined with dexamethasone in the treatment of tuberculous pleurisy by chest could quickly eliminate pleural effusion and reduce the thickening pleural adhesions.