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小窝蛋白-1的生物学功能及其急性肺损伤 被引量:2

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摘要 概述 一、小窝小窝最早是由Palade于1953年在电镜下观察内皮细胞时发现,当时称之为"质膜囊泡",而"小窝"一词是由Yamada在1955年提出,描述胆囊上皮细胞上"与细胞外相交流的小口袋、囊泡、洞穴或凹陷"。随后,在其他多种细胞上也发现类似结构,其直径为50~100 nm,呈烧瓶形或Ω形,
作者 高磊 孙耕耘
出处 《临床肺科杂志》 2011年第12期1919-1921,共3页 Journal of Clinical Pulmonary Medicine
基金 国家自然科学基金资助项目(编号:81070054)
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  • 1Sun Y, Hu G, Zhang X, et al. Phosphorylation of caveolin-1 regu- lates oxidant induced pulmonary vascular permeability via paracellu- lar and transcellular pathways [ J]. Circ Res, 2009,105:676 - 685.
  • 2Bento-Abreu A, Velaso A, Polo-Hem6ndez E, et al. Albumin en- docytosis via megalin in astrocytes is caveolae-and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid [J]. J Neurochem. 2009.111(1) ..49 -60.

同被引文献13

  • 1于涓瀚,韦强,齐凤杰,徐洪涛,王恩华.窖蛋白-1在肺癌中的表达及意义[J].中华病理学杂志,2006,35(11):664-668. 被引量:19
  • 2Anderson RG,Jacobson K.A role for lipid shells in targeting proteins to caveolae,rafts,and other lipid domains[J].Science,2002,296(5574):1821-1825.
  • 3Carver LA,Schnitzer JE.Caveolae:mining little caves for new cancer targets[J].Nat Rev Cancer,2003,3(8):571-581.
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  • 5Park JH,Han HJ.Caveolin-1 plays important role in EGF-induced migration and proliferation of mouse embryonic stem cells:involvement of PI3K/Akt and ERK[J].Am J Physiol Cell Physiol.2009,297(4):C935-944.
  • 6Li L,Yang G,Ebara S,et al.Caveolin-1 mediates testosterone-stimulated survival/clonal growth and promotes metastatic activities in prostate cancer cells[J].Cancer Res.2001,61(11):4386-4392.
  • 7Fine SW,Lisanti MP,GalbiatiF,et al.Elevated expression of caveolin-1 in adenocareinoma of the colon[J].Am J Clin Pathol,2001,115(5):719--724.
  • 8Kato K,HidaY,Miyamoto M,et al.Overexpression of caveolin-1 in esophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage[J].Caneer,2002,94(4):929-933.
  • 9Vicent S,Garayoa M,Lopez-Picazo JM,et al.Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients[J].Clin Cancer Res,2004,10(11):3639-3649.
  • 10de Melo M,Gerbase MW,Curran J,et al.Phosphorylated extracellular signal-regulated kinases are significantly increased in malignant mesothelioma[J].J Histochem Cytochem,2006,54(8):855-861.

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