肱踝动脉脉搏波传导速度在健康体检中的应用及相关因素分析

Influential factors of brachial-ankle artery pulse wave velocity in healthy subjects

目的探讨肱踝动脉脉搏波传导速度（baPWV）在健康体检中的应用及其相关因素。方法选择2010年在北京协和医院健康医学部接受定期健康体检符合入选条件的750例健康体检者为受试者，测定其双侧baPWV，使用多元线性回归分析评估baPWV与性别、年龄、体重指数、动脉血压、踝肱指数及血生化指标的相关性，并建立线性回归方程。结果最终716例资料完整的受试者平均baPWV为（1224±162）cm／s；其中男503例，平均baPWV为（1257±159）cm／s；女213例，平均baPWV为（1144±143）cm/s，差异有统计学意义（P〈0．01）。多元线性回归分析显示，性别、年龄、平均动脉压以及血同型半胱氨酸浓度是baPWV的独立相关因素，线性回归方程为：双侧平均baPWV=6．635×年龄＋7．285×平均动脉压＋2．682×同型半胱氨酸浓度-64．334×性别（男性=0，女性=1）＋347．500。结论性别、年龄、平均动脉压以及血同型半胱氨酸浓度是baPWV的独立相关因素。

Objective To investigate the influential factors of brachial-ankle artery pulse wave velocity （baPWV） in healthy individuals. Methods Total 716 healthy subjects including 503 males and 213 females, who underwent health check up in 2010, were enrolled in the study Bilateral baPWV was examined in all subjects and multiple factor linear regression was applied to evaluate the correlations of baPWV with sex, age, body mass index, arterial blood pressure, ankle-brachial index and biochemical variables. Results The mean baPWV of 716 healthy subjecs was （ 1224 ± 162） em/s, and there was significant difference between men and women [ （1257 ±159） cm/s vs. （1144 ±143） cm/s]. There was a significant linear correlation of baPWV with sex, age, mean arterial blood pressure and plasma homocysteine concentration ; and the linear regression equation was ： mean PWV = 6. 635 × age ＋ 7. 285 × mean arterial blood pressure ＋ 2. 682 × homocysteine concentration - 64. 334 × sex ＋ 347. 500 （ sex ： man = 0,woman = 1 ）. Conclusion Age, sex, mean arterial blood pressure and plasma homocysteine concentration are independent influential factors of baPWV.