治疗糖尿病天然化合物研究进展

Research Progress of natural compounds used in the treat ment of Diabetes Mellitus

目的糖尿病即为中医的消渴病,对人类身心健康构成了严重的威胁。尽管西药对糖尿病具有较好的降血糖作用,然而存在着各种的毒副作用。中药在中医理论的指导下,治疗糖尿病及其并发症已有2000年的历史。随着天然药物化学和现代医学的发展,大量的天然活性化合物被分离出来,并通过各种机制作用于糖尿病。因此,本文主要对近期报道的治疗糖尿病的天然活性化合物进行了综述,包括了黄酮、生物碱、萜类、蒽醌类等。目的在于引起人们对天然化合物治疗糖尿病及其并发症的关注。

Diabetes mellitus （DM）, refered to as Xiao Ke Bing in traditional Chnese medicine （TCM）, is becoming a serious threat to mankind health. Although some synthetic drugs have been employed to lessen blood sugar presenting eutherapeutic effects, there are still unfortunate toxicity and side effects. TCM, performing a good clinical practice in DM and its complications, has been used in China for 2000 years in accordance with TCM theory. With the development of natural medicine chemistry and modern medicine, numerous potentially active natural compounds have been isolated, which mechanism was revealed in a variety of pathways. From this point of view, this paper reviews active natural compounds used as treatment of DM reported presently, including flavonoids, alkaloids, terpenoids and anthraquinones. The present review aim to arouse wide concern on the natural compounds used in the treatment of DM and its complications.