奥沙普秦的线性扫描极谱法测定

Linear Scanning Polarographic Determination of Oxaprozin

用线性扫描极谱法和循环伏安法研究奥沙普秦在0.05mol.L-1HAc-NaAc缓冲溶液(pH5.18)中的电化学行为。奥沙普秦于-1.221V(vs.SCE)处产生一灵敏的吸附波,奥沙普秦浓度在4.0μg.L-1～2000.0μg.L-1范围时,其一次微分线性扫描峰电流与奥沙普秦浓度呈良好的线性关系,相关系数r=0.99920(n=15),检出限为2.4μg.L-1。对200.0μg.L-1奥沙普秦溶液进行6次平行试验,RSD为1.02%,回收率在94.3%～96.2%之间,方法可用于其在片剂中含量的测定。

The electrochemical behavior of Oxaprozin was studied by linear scanning polarographic and cyclic voltammograms method.In an acetate buffer solution of pH 5.18,a sensitive reductive wave of Oxaprozin appeared at 1.221V（vs.SCE）.The linear relationship between the peak current and the Oxaprozin concentration in the range of 4.0μg·L-1～2000.0μg·L-1（r=0.9992,n=15） was observed.The detection limit of the method was 2.8μg.L-1.RSD obtained from the data of 6 independent determinations at the concentration level of 200.0μg.L-1 was 1.02%,Recoveries obtained were in the range of 94.3%～96.2%.This method can be applied to the determination of Oxaprozin in tablets.