洋葱伯克霍尔德菌的临床分布及耐药性分析

The analysis of the clinical distribution and drug resistance of Burkholderia Cepacia

目的了解2009-2010年东莞市石龙博爱医院临床分离的洋葱伯克霍尔德菌的标本来源、临床分布和耐药性,为控制院内感染提供依据。方法采用ATB Expression细菌鉴定仪和纸片扩散法对东莞市石龙博爱医院临床分离的洋葱伯克霍尔德菌进行鉴定和药敏试验。结果 2009-2010年共分离出62株洋葱伯克霍尔德菌,痰标本中分离菌株数占96.8%（60/62）,主要来自于重症监护病房,占95.2%（59/62）。药敏试验结果显示,氨基糖苷类、喹诺酮类和亚胺培南的耐药率较高,均在80.0%以上;哌拉西林、哌拉西林/他唑巴坦和复方新诺明的耐药率较低,均在10.0%左右。结论洋葱伯克霍尔德菌对多种抗菌药物具有较高的耐药性,临床治疗应根据抗菌药物敏感性为依据。

Objective To investigate the source,clinical distribution and drug resistance of clinically isolated Burkholderia Cepacia specimens in our hospital from 2009 to 2010,and to provide basis for the preventing of infections in hospital.Methods The ATB expression bacterial identification system and K-B agar diffusion method were used to identify and test the drug sensitivity of the isolated Burkholderia Cepacia in our hospital.Results 62 strains Burkholderia Cepacia were isolated from 2009 to 2010,in which sputum accounted for 96.8%（60/62）.Most of them came from the ICU,accounted for 95.2%（59/62）.Drug resistance test results showed that the resistance rate of aminoglycosides,fluoroquinolones and imipenem had higher drug sensitivity rate（over 80%）;while the drug resistance rate of piperacillin,piperacillin / tazobactam and cotrimoxazole were lower than 10%.Conclusion Burkholderia cepacia has a high resistance rate to many antimicrobial drugs.Clinical treatment should be based on the result of antimicrobial susceptibility.