EB病毒感染与基质金属蛋白酶-7在胃癌发生中的作用

Effect of MMP-7 with EBV in gastric carcinoma

目的探讨EB病毒(EBV)感染、基质金属蛋白酶-7(MMP-7)在胃癌发生和发展中的相互作用。方法采用原位核酸杂交技术检测304例胃癌和相应癌旁组织中EBV小RNA(EBER1)的表达,确证EBV相关胃癌(EBVaGC)。采用免疫组化技术检测20例EBVaGC、46例临床指标与之匹配的EBV阴性胃癌(EBVnGC)以及66例相应癌旁组织MMP-7的表达,结合患者临床病理资料进行综合分析。结果 (1)胃癌组织EBV阳性率为6.58%,显著高于相应癌旁组织,差异有统计学意义(P<0.05)。(2)EBVaGC和EBVnGC中MMP-7的阳性率分别为65.00%和60.87%,差异无统计学意义(P>0.05)。结论 EBV感染与部分胃癌的发生相关,但未观察到EBV感染对胃癌组织中MMP-7表达的影响。

Objective To detect the effect of MMP-7 with epstein-barr virus（EBV） in the gastric carcinoma（GC）.Methods EBV-encoded small RNA1（EBER1） was detected by in situ hybridization（ISH） in 304 GC and corresponding para-carcinoma tissues.The expression of MMP-7 in 20 EBVaGC,46 EBV-negtive gastric carcinomas（EBVnGC） tissues and 66 corresponding para-carcinoma tissues were detected by immunohistochemistry.Results（1）The positive rate of EBV（6.58%） in GC tissues was higher than that in the corresponding para-carcinoma tissues.There was statistical significance（P0.05）.（2）The positive rate of MMP-7 in EBVaGC was 65.00% and 60.87% in EBVnGC.There was no significant difference（P0.05）.Conclusion EBV infection is related with some GC,but its influence on the expression of MMP-7 was not observed.