慢性阻塞性肺疾病患者继发铜绿假单胞菌肺炎的耐药性调查

Antibiotics resistance of Pseudomonas aeruginosa causing secondary pneumonia in patients with chronic obstructive pulmonary diseases

目的了解医院慢性阻塞性肺疾病(COPD)患者肺部感染铜绿假单胞菌(PAE)的耐药性,为临床医师正确诊断疾病与合理用药提供试验依据。方法铜绿假单胞菌培养鉴定严格按照《全国临床检验操作规程》进行;药物敏感试验采用K-B法,结果判断按照CLSI折点评价;采用WHONET 5.4版本统计分析试验数据。结果 133株铜绿假单胞菌对亚胺培南和美罗培南耐药率分别为29.3%、31.6%,对其他常用抗菌药物也产生了不同程度的耐药性;铜绿假单胞菌泛耐药株检出率为12.0%。结论 COPD患者肺部感染铜绿假单胞菌的耐药性已十分严重,临床医护人员应加强监测与控制力度。

OBJECTIVE To understand the antibiotics resistance of Pseudomonas aeruginosa （PAE） causing pneumonia from patients with chronic obstructive pulmonary diseases （COPD） and provide the experimental evidence for clinically correct diagnosis of diseases and reasonable use of antibiotics. METHODS Referring to National guide to clinical laboratory procedures, PAE were cultured and identified. The antibiotical susceptibili- ty testings were performed by K-B methods. The susceptibility testings results were assessed according to CLSI breakpoints and analyzed statistically by WHONET 5.4 software. RESULTS The resistance rates of imipenem and meropenem were 29. 3% and 31. 6%, respectively. The varying antibacterial resistance existed in the other commonly used antibiotics. The detection rate of pan-resistant strains was 12.0%. CONCLUSION The antibiotics resistance of PAE causing pneumonia from patients with COPD is increasingly serious. We should strengthen monitoring and controlling of it.