进展期白癜风患者血清催乳素检测分析

Analysis of prolactin level of 205 aggressive-phase vitiligo patients and its clinical significance

目的探讨血清催乳素（PRL）水平与进展期白癜风发生发展的关系。方法采用化学发光法测定205例进展期白癜风患者（病例组）的PRL水平，并与健康对照组（98例）比较。结果（1）对照组与病例组催乳素水平数据样本均数及总体分布差异有统计学意义（P〈0．05），并且病例组水平[（275．96±178．51）μIU／ml]低于对照组[（282．98±115．39〉μIU／ml]；（2）女性病例组的催乳素水平[（288．68±198．45）μIU／ml]与女性对照组[（303．82±121．62）μIU／ml]差异有统计学意义（P〈0．05）。男性病例组催乳素水平[（256．54±141．72）μIU／ml]与男性对照组[（236．43±84．67）μIU／ml]差异则无统计学意义（P〉O．05）。结论催乳素可能并非直接参与或导致白癜风发生及发展。因此它无法作为一项诊断检测指标用于衡量白癜风患病程度，更无法作为中医或维吾尔医学理论中各自癜风辨证分型的诊断依据。

Objective To explore the relation between the serum prolaetin level and the development of aggressive-phase vitiligo. Methods The peripheral blood serum of 205 aggressive-phase vitiligo patients（ trial group） and 98 healthy volunteer（control group） were assayed by chemiluraineseence analysis. Results （ 1 ） The data of the prolaetin levels and the overall distribution of sample mean had statistically significant differences between the control group and trial group（ P 〈 0. 05 ）. The PRL level of the trial group [ （ 275, 96 ± 178.51 ） μIU/ml] was significantly lower than that of the control group[ （282, 98 ±115.39）μIU/ml] （P 〈 0.05 ）. （2）The PRL level of the female trial group [ （288.68 ± 198.45） μIU/ml ] was significantly different from the female control group [ （ 3138.82 ± 121.62） μIU/ml ] （ P 〈 0.05 ）, and the PRL level between the male trial group[ （256, 54 ± 141.72） μIU/ml ] and the male control group [ （236.43 ± 84.67） μIU/ml] had no significant differences （ P 〉 0. 05）. Conclusion PRL should not directly result in or participate in development of vitilign..So it could not be a diagnostic tests to measure the stage of vitilign and the diagnosis basis for vitiligo＇s syndrome differentiation of chinese-medicine or Uygur-medieine.