高龄孕妇产前超声筛查的临床意义

Clinical significance of prenatal ultrasound screening in pregnart women with advanced maternal age

目的探讨对高龄孕妇实施系统产前超声筛查的诊断价值及临床意义。方法统计10630例接受胎儿畸形产前超声检查孕妇资料，对其中712例高龄孕妇（预产期年龄〉35周岁）实施系统产前超声筛查，并随访所有高龄孕妇妊娠结果，胎儿畸形以产后最终诊断为标准，同时以非高龄孕妇筛查作为对照组进行比较，评估产前超声诊断的价值。结果712例高龄孕妇中，产前超声诊断胎儿畸形32例（4．49％），单发畸形15例，复合畸形17例，漏诊4例，畸形检出率88．88％（36／32）。对照组9918例孕妇产前超声诊断胎儿畸形243例（2．45％）。结论高龄孕妇畸形发生率高于低龄孕妇，对高龄孕妇根据超声筛查结果行产前诊断，可以能有效地降低畸形儿的出生率及漏诊率。

Objective To investigate the implementation of the system of older pregnant women prenatal ultrasound screening for the diagnosis and clinical significance. Methods Clinical data from March 2004 to April 2009 a total of 10 630 cases of pregnant women receiving prenatal ultrasound examination of fetal malformation data, of which 712 eases of advanced maternal age（ expected date of birth aged≥35 years） to implement the system of prenatal ultrasound screening and follow-up of all maternal age pregnancy outcome, the final post-natal diagnosis of fetal malformations in the standard, both young women screened as a control group for comparison to assess the value of prenatal ultrasound diagnosis. Results 712 cases of advanced maternal age, prenatal ultrasound diagnosis of fetal malformations in 32 cases, abnormalities occur in approximately 4.49% , single abnormal in 15 cases, complex deform- ity in 17 eases, missed 4 cases of malformation detection rate was 88.88% （36/32）. Control group,9918 eases of prenatal ultrasound diagnosis of fetal malformations 243 cases, 2. 45% incidence of deformity （243/9 918 ）. Conclusion Older pregnant women, prenatal ultrasound screening for malformations occur in approximately 4.49%, higher than the detection rate with screening younger women 2.45% , of older pregnant women according to the results of prenatal diagnostic screening could be effective in reducing the birth rate of deformed children and the rate of misdiagnosis.