中药复方对非酒精性脂肪肝大鼠血清TC、TG、HDL的影响

The effect of compound traditional Chinese medicine on the level of TC,TG,HDL to NA FLD

目的探讨中药复方对非酒精性脂肪肝大鼠血清TC、TG、HDL的影响。方法采用高脂饮食法建立大鼠非酒精性脂肪肝病模型,采用全自动生化仪检测大鼠血清中TC、TG、HDL的含量,采用HE染色法观察大鼠肝细胞脂肪变性情况。结果给药组大鼠血清中TC、TG、HDL的含量与对照组比较有统计学意义(P<0.05);中药复方高剂量组与阿托伐他汀组比较,无明显差异(P>0.05);中药复方低剂量组与高剂量组和阳性对照组相比有显著性差异(P<0.05);中药复方高剂量组、中剂量组给药后肝细胞脂肪变性情况明显好转,与对照组相比有显著性差异(P<0.05),与阳性对照组相比无明显差异(P>0.05)。结论中药复方对非酒精性脂肪肝大鼠有很好的治疗作用。

Objective To study the effect of compound traditional Chinese medicine on the level of TC,TG,HDL to NAFLD.Methods High fat diet method was used to establish NAFLD model,automatic biochemical analyzer was used to detect the contents of TC,TG,HDL in serum of rats,HE staining was used to observe the rat fatty degeneration of liver cells.Results The administration compared with control group on the level of TC,TG,HDL in rat serum hadstatistical significance（P0.05）;Traditional Chinese medicine compound in high dose group compared with atorvastatin group had no significant difference（P0.05）;Traditional Chinese medicine compound of low dose group compared with high dose group and positive control group had significantly difference（P0.05）;Chinese medicine compound high dose group,middle dose group after administration of fatty degeneration of liver cells was significantly improved,compared with the control group had significant differences（P0.05）,compared with the positive control group had no significant difference（P0.05）.Conclusions Compound traditional Chinese medicine has a very good therapy on NAFLD.