维持性血液透析患者心血管并发症危险相关因素的研究

On the risk correlative factors of cardiovascular complications in maintenance hemodialysis patients

目的:研究维持性血液透析患者血脂、瘦素、微炎症状态与心血管并发症的相关关系。方法:测定92例维持性血液透析(MHD)患者及23例健康者血脂、瘦素(Leptin)、血C反应蛋白(CRP)等指标。结果:MHD患者出现血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、Leptin、CRP明显升高,高密度脂蛋白胆固醇(HDL-C)明显减低,其CRP与TG、LDL-C成正相关,与HDL-C成负相关。结论:MHD患者存在发生心血管事件的多种危险因素,针对性地干预这些因素有可能降低心血管事件的发生率和病死率,改善MHD患者的预后。

Objective：To study the correlations between serum lipid,leptin,microinflammatory state and cardiovascular complications in nephropathy maintenance hemodialysis（MHD）patients.Methods： The lipid profile,leptin,serum C-reactive protein（CRP） were measured in 92 MHD patients and 23 healthy subjects.Results：The serum triglyceride（TG）,low density lipoprotein cholesterol （LDL-C）,leptin and CRP were obviously increased in the MHD patients,while the high density lipoprotein cholesterol（HDL-C）were significantly decreased in the MHD patients.There were positive correlation of CRP with TG,LDL-C and negative correlation between HDL-C.Conclusion：There are various risk factors of cardiovascular occurrences in MHD patients.So,the intervention of these risk factors might decrease the occurrence and mortality rates of cardiovascular events and improve the prognosis of MHD patients.