1Joukov V,Pajusola K,Kaipainen A,et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Fit4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases[J]. EMBO J, 1996,15 (2) :290-298.
2Skobe M, Hawighorst T,Jackson D G, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis[J]. Nat Med,2001,7 : 192-198.
3Krishnan J, Kirkin V, Steffen A, et al. Differential in vivo and in vitro expression of vascular endothelial growth fac- tor (VEGF-C) and VEGF-D in tumors and its relation- ship to lymphatic metastasis in immunocompetent rats [J]. Cancer Res,2003,63(3) :713-722.
4Mattila M M,Ruohola J K,Karpanen T,et al. VEGF-C in- duced lymphangiogenesis is associated with lymph node metastasis in orthotopoic MCF-7 tumors[J].Int J Cancer, 2002,98(6) : 946-951.
5Ochi N, Matsuo Y, Sawai H. Vascular endothelial growth factor-C secreted by pancreatic cancer cell line promotes lymphatic endothelial cell migration in an in vitro model of tumor lymphangiogenesis [J]. Pancreas, 2007,34 (4) :444-451.
6Kodama M, Kitadai Y, Tanaka M, et al. Vascular endothe- lial growth factor C stimulates progression of human gas- tric cancer via both autocrine and paracrine mechanisms [J]. Clin Cancer Res,2008,14(22) : 7205-7214.
7Feng Y, Wei W, Hu J, et al. Expression of VEGF-C and VEGF-D as significant markers for assessment of lym- phangiogenesis and lymph node metastasis in non-small cell lung cancer[J]. Anat Rec(Hobocan),2010,293(5) 802-812.
8Takizawa H, Kondo K, Fujino H. The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metas- tasis in non-small cell lung cancer[J].Cancer, 2006,95 (1) :75-79.
6Sun HC,Zhuang PY,Qin LX,et al.Incidence and prognostic values of lymph node metastasis in operable hepatocellular carcinoma and evaluation of routine complete lymphadenectomy.J Surg Oncol,2007,96:37-45.
7Zeng ZC,Tang ZY,Fan J,et al.Consideration of role of radiotherapy for lymph node metastases in patients with HCC:retrospective analysis for prognostic factors from 125 patients.Int J Radiat Oncol Biol Phys,2005,63:1067-1076.
8Kodama J,Hasengaowa,Kusumoto T,et al.Association of CXCR4 and CCR7 chemokine receptor expression and lymph node metastasis in human cervical cancer.Ann Oncol,2007,18:70-76.
9Kaifi JT,Yekebas EF,Schurr P,et al.Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer.J Natl Cancer Inst,2005,97:1840-1847.
10Ishikawa T,Nakashiro K,Hara S,et al.CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma.Int J Oncol,2006,28:61-66.
2BAUVOIS B. New facets of matrix metalloproteinases MMP -2 and MMP - 9 as cell surface transducers: outside - in signaling and relationship to tumor progression [ J ]. Biochim Biophys Acta, 2012, 1825(1) : 29 -36.
3JEDRYKA M, CHROBAK A, CHELMONSKA SOYTA A, et al. Matrix metalloproteinase (MMP) - 2 and MMP - 9 expression in tumor infiltrating CD3 lymphocytes from women with endometrial cancer[ J]. Int J Gynecol Cancer, 2012, 22 (8) : 1303 -1309.
4PRATHEESHKUMAR P, KUTYAN G. Nomilin inhibits tumor -spe- cific angiogenesis by downregulating VEGF, NO and proinflammatory cytokine profile and also by inhibiting the activation of MMP -2 and MMP-9[J]. Eur J Pharmacol, 2011, 668(3) : 450 -458.