佛山地区先天性甲状腺功能减低症诊治与随访十年回顾

The diagnosis therapy and follow-up for the congenital hypothyroidism in ten years retrospect

目的探讨先天性甲状腺功能减低症(congenital hypothyroidism,CH)的筛查、诊断、治疗与随访工作的意义及存在的问题。方法对佛山市新生儿筛查中心确诊的201例CH患儿的临床资料进行回顾总结。结果新生儿疾病筛查是早期诊断甲低的最佳途径;暂时性甲低初始治疗剂量及停药时间有待进一步探讨;结论早期甲状腺素的替代治疗,完善的专科随访,能保证95%的甲低患儿智能发育达到正常。

Objective： To study the significance and the problem existent of screening, diagnosis, therapy and follow - up of congenital hypothyroidism. Methods： The clinical data from Foshan neonate disease screening center of 201 children with congenital hypothyroidism was reviewed. Results： Neonate disease screening was the best way of early diagnosis of congenital hypothyroidism; the incipient dosage of therapy of temporary congenital hypothyroidism and the time of with drawal was to be further investigated. Conclusion ： Early substituted therapy of thyroxinic and consummate follow - up of special course of study could guarantee that the 95% of children with congenital hypothyroidism possesed normal intellectual development.