序贯疗法根除初治失败幽门螺杆菌疗效观察被引量：1

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摘要目的分析总结雷贝拉唑、阿莫西林、克拉霉素、替硝唑组成的10日序贯疗法根除初治失败幽门螺杆菌(Helicobacter pylori,Hp)的疗效。方法将2009年5月2011年5月在消化科门诊及住院经胃镜确诊的胃、十二指肠溃疡患者65例,经标准三联疗法治疗4周后Hp仍阳性的患者随机分为两组,治疗组33例前5d用雷贝拉唑10mg、阿莫西林1.0,每日2次口服,后5d用雷贝拉唑10mg、克拉霉素500mg、替硝唑500mg,每日2次口服;对照组32例用雷贝拉唑10mg、枸橼酸铋钾600mg、呋喃唑酮0.1g、阿莫西林1.0g,每日2次,疗程10d。停药4周后复查Hp。结果治疗组Hp根除率81.8%,对照组75.0%,两组比较无统计学意义(P>0.05)。不良反应率分别为12.1%和34.3%,两组比较有统计学意义(P<0.05)。结论序贯疗法对初治失败Hp根除率高于四联疗法但无统计学意义,不良反应率低于对照组,可作为根除初治失败Hp的一种有效方案。

作者黄忠李智侯聪

机构地区自贡市第一人民医院

出处《华西医学》 CAS 2011年第10期1539-1540,共2页 West China Medical Journal

关键词序贯疗法四联疗法幽门螺杆菌

分类号 R57 [医药卫生—消化系统]

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