NT-proBNP与急性心肌梗死患者预后关系及在心肌梗死中的应用价值

The clinical value of N-Terminal Pro Brain Natriuretic Peptide(NT-ProBNP) in the Prognosis of Patients with Acute Myocardial Infarction

目的分析探讨急性心肌梗死患者血浆NT-proBNP的浓度与患者预后情况的关系,研究NT-proBNP血浆浓度在心肌梗死中的临床意义。方法回顾性分析我院收治的88例急性心肌梗死患者作为观察组,选择非急性心肌梗死的冠心病患者68例作为对照组,均采用酶联免疫吸附法测定患者住院后48h内血浆NT-proBNP的浓度,观察2组患者住院期间预后情况。结果观察组的急性心肌梗死患者血浆NT-proBNP浓度在发生心梗后显著比对照组升高,并且NT-proBNP血浆浓度越高,住院期再发心血管事件的机率越大。结论 NT-proBNP的血浆浓度关系着急性心肌梗死患者的预后情况,是心梗患者早期心血管事件的重要预测因子,在心梗中可作为预测心血管事件的判断因素。

Objective To ananlyse the clinical value of N-Terminal Pro Brain Natriuretic Peptide（NT-ProBNP） level in the Prognosis of Patients with Acute Myocardial Infarction and explore the clinical relationship between NT-proBNP and Myocardial Infarction. Methods Compare the different of the plasma concentrations between 88 patients with Myocardial Infarction and 68 Coronary Heart Disease patients.All of them measured the plasma concentrations of NT-proBNP by ELISA within 48 hours after they were in hospital.88 patients were then followed to survey the prognosis in hospital in order to survey whether they have cardica events or not.Results Plasma NT-proBNP concentrations in Acute Myocardial Infarction patients were showed much higher than Coronary Heart Disease patients.The higher level of plasma NT-proBNP also cause cardiovascular events.Conclusion From the present study,we confirm that the elevated NT-proBNP concentration related to the bad prognosis in patients with Acute Myocardial Infarction,even occurring a cardiac events after Acute Myocardial Infarction.The plasma concentration of NT-proBNP can be used as an predictor of poor outcomes in Acute Myocardial Infarction.patients.