动脉途径应用依达拉奉治疗急性脑梗死

The effect of intra-arterial injection of edaravone on acute cerebral infarction

目的观察动脉途径应用依达拉奉治疗急性脑梗死的疗效,寻找更加有效的依达拉奉使用途径。方法 164例急性脑梗死患者,在治疗前、治疗后及治疗14d三个时间点,对比观察应用普通动脉导管及超选择微导管推注依达拉奉与静脉输注之间的神经功能缺损情况,比较各种途径的疗效差异。结果各途径患者治疗前、治疗后及治疗14 d后神经功能缺损评分进行性下降(P<0.05;治疗后即刻疗效评价,静脉输注组有效率为49.33%,动脉推注组有效率为65.67%,超选择推注组有效率为77.27%,三组间有效率比较有明显差异(P<0.05);治疗14 d后疗效评价发现,静脉输注组有效率为81.33%,动脉推注组有效率为88.06%,超选择推注组有效率为86.36%,三组间比较发现动脉推注及超选择推注14 d有效率较静脉输液显著提高(P<0.05),但动脉推注及超选择推注之间14 d有效率无统计学差异(P>0.05)。结论动脉途径明显提高了依达拉奉治疗急性脑梗死的有效率,但普通导管动脉推注更易于操作、更安全。

Objective To observe the effect of intra-arterial injection of edaravone on acute cerebral infarction,find more effective ways of using edaravone. Methods We observed the neurological deficit of 164 patients of acute cerebral infarction at three time points（before treatment,during treatment and 14 days after treatment）,using edaravone from different ways（common arterial catheter,superselective microcatheter injection and intravenous infusion）,compared the effectiveness of different ways. Results The neurological deficit scores were decreased with treating（P0.05）.There were significant differences of immediate effectiveness in different ways（P0.05） after treatment.The effective rates of three ways were 49.33%,65.67% and 77.27% respectively.We found the effectiveness of treatment on 14 d was difference： the effective rate of 81.33%,88.06% and 86.36%,respectivery.Intra-arterial injection was more effeciant compared with the intravenous infusion（P0.05）,but there was no difference between the common arterial catheter injection and superselective microcatheter injection（P0.05）. Conclusions Intra-arterial injection of edaravone significantly improves the effectiveness of treatment of acute cerebral infarction,but we believe that the common arterial catheter injection is easy safe and effective.