抑制IL-6／STAT3信号通路对脓毒症大鼠肝损伤的影响被引量：2

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摘要脓毒症及其导致的MODS仍然是临床医学的棘手问题。研究表明，多种信号通路参与了全身炎症反应和组织损伤的病理过程。信号转导和转录激活因子3（signal transducer and activator of transcription3，STAT3）作为脓毒症时细胞内的主要信号转导系统之一，与脓毒症主要炎症介质IL一6的释放密切相关，在脓毒症的急性组织损害中发挥着重要作用。但是，抑制IL-6／STAT3信号通路是否影响脓毒症时的全身炎症反应或组织损害，目前仍不清楚。

作者郭毅斌陈莉萍郑庆亦陈锦河蔡少甫曹红卫王宁郑江肖光夏

机构地区解放军第一七五医院（厦门大学附属东南医院）全军烧伤中心解放军第三第三军医大学附属西南医院综合实验研究中心第三军医大学全军烧伤研究所

出处《中华创伤杂志》 CAS CSCD 北大核心 2011年第11期1049-1052,共4页 Chinese Journal of Trauma

基金 2010军队临床高新技术重大资助项目（2010gxjs029）南京军区科学科技创新资助项目（08Z022）

关键词 STAT3 信号通路 IL-6 脓毒症信号转导和转录激活因子肝损伤 ACTIVATOR 全身炎症反应

分类号 R45 [医药卫生—治疗学]

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参考文献12

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