期刊文献+

泪腺多形性腺瘤组织病理学研究 被引量:8

Pathological analysis of lacrimal pleomorphic adenoma
下载PDF
导出
摘要 背景泪腺多形性腺瘤是眼眶部最常见的泪腺上皮性肿瘤,组织学上虽表现为良性,但具有易复发和恶变的特点。其组织学表现呈现多样性,常具有与其他泪腺上皮性肿瘤相同的组织学结构。目的探讨泪腺多形性腺瘤不同病理亚型的组织学特点及其与肿瘤复发的关系,并提高对其组织病理学类型的认识。方法收集1966--2010年在中山大学中山眼科中心病理室存档的181例泪腺多形性腺瘤的基本临床资料和组织石蜡标本,并重新切片行苏木精一伊红染色,观察肿瘤内各组分形态、结构特点及其与肿瘤复发的关系。结果181例泪腺多形性腺瘤可分为上皮细胞为主型90例(49.7%)、问质丰富型38例(21%)以及中间型(上皮和间质成分比例相当)53例(29.3%)。86.5%的复发泪腺多形性腺瘤为间质丰富型,显著高于其他两种类型(χ2=120.896,P=0.000)。在159例有包膜的肿瘤中,138例(86.7%)可见包膜较薄(局部厚度〈20Ixm),尤其在间质丰富型肿瘤中往往有大片的薄包膜区域,间质丰富型包膜内肿瘤卫星灶或芽状突起比例显著高于其他两种类型(χ2=80.715,P=0.000)。肿瘤上皮成分包含立方形、鳞状上皮、浆细胞样、梭形、透明样和基底样细胞,其中立方形细胞最为常见,鳞状细胞次之。上皮细胞排列方式多样,有导管状、囊状、片状实体及小梁网状结构,其中以导管状结构最为常见。肿瘤内的间质成分包括黏液基质、玻璃样变组织、脂肪细胞以及软骨或钙化组织,其中黏液成分最为常见。结论复发性泪腺多形性腺瘤以间质丰富型常见,其包膜受侵犯可能是肿瘤复发的原因之一。掌握泪腺多形性腺瘤上皮及间质成分的多种形态及排列结构,有助于病理医师的正确诊断。 Background Lacrimal gland pleomorphie adenoma (LGPA) is the most common epithelial neoplasms of the lacrimal glands. Though its histopathologieal feature is benign,recurrence and malignant transition is common. The histopathologica feature of LGPA vary and resemble other lacrimal gland tumors. Objective This survey was to explore the histopathologieal features of different subtypes of LGPA and their relationships with tumor recurrence,and improve the knowledge of histopathologieal characteristics of LGPA. Methods A retrospective study of 181 consecutive cases pathologically diagnosed as LGPA during 1966- 2010 years was performed to investigate the clinical and histopathologieal characteristics. Results One hundred and eighty-one LGPAs were classified as cell-rich type in 90(49.7% ),stroma-rich type in 38 cases(21% ),and intermediate type in 53 cases ( 29.3% ). 91.7% of all tumors showed areas with thin( 〈20 txm) capsules independent of the tumor subtype. Tumors of stroma-rich subtype showed greater thin-capsule regions. 86.5% recurrent LGPAs belonged to stroma-rich subtype (χ2 = 120. 896,P=0. 000) ,which had a higher rate of pseudopodia or satellite nodules in the capsules than other two subtypes did(χ2= 80. 715, P = 0. 000). Cuboidal cells were the most commonly found cellular type followed by squamous cells. Duct-like structures were the most frequent patterns formed mainly by epithelial cells. Myxoid stromawas the most frequently found mesenchymal-like tissue. Conclusions The tendency of recurrence and invadation of capsule may contributed to the high recurrence rate in stroma-rich type of LGPAs. The knowledge of the immense variety of cells,architectures and morphological characteristics of LGPA are essential for a correction of pathological diagnosis.
出处 《中华实验眼科杂志》 CAS CSCD 北大核心 2011年第11期978-982,共5页 Chinese Journal Of Experimental Ophthalmology
基金 国家自然科学基金资助项目(30672276)
关键词 泪腺 肿瘤/多形性腺瘤 病理学/诊断 分型 包膜 复发 Lacrimal gland Tumor/pleomorphic adenoma Pathology/diagnosis, classification Encapsulation Recurrence
  • 相关文献

同被引文献70

引证文献8

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部