血栓弹力图对急性脑梗死患者阿司匹林疗效监测价值

Thrombelastography in monitoring aspirin effect on acute ischemic stroke

目的探讨血栓弹力图检测对急性脑梗死患者阿司匹林疗效的监测作用。方法对60例口服阿司匹林的急性脑梗死患者分别进行光学法血小板聚集率和血栓弹力图检测,比较2种检测方法的结果。结果血小板聚集率和血栓弹力图检测血小板抵抗有较好的一致性(Kappa=0.76)。结论血栓弹力图检测对服用阿司匹林的急性脑梗死患者的药物疗效有较高临床价值,可用于评价抗血小板药物的临床疗效,指导临床治疗。

Objective To study two different methods to monitor the effect of aspirin on acute ischemic stroke. Methods A total of 60 patients with acute ischemic stroke treated with oral aspirin received platelet aggregation test and thrombelastography. Results Two methods had a good consistency in testing aspirin resistance（Kappa=0. 76）. Conclusion Thrombelastography has a high clinical value to monitoring aspirin effect on acute ischemic stroke, and it can be used to evaluate the therapeutic effect of antiplatete drugs and guide clinical treatment.