2型糖尿病患者乙型肝炎病毒血清标志物结果分析

Seroprevalence of hepatitis B virus infection in type 2 diabetes mellitus

目的探讨2型糖尿病与乙型肝炎病毒感染的关系。方法采用ELISA法检测588例2型糖尿病患者(DM2组)及同期健康者体检排除糖尿病者604例(对照组)乙型肝炎病毒血清学标志物并比较阳性率。结果 DM2组乙型肝炎表面抗原阳性102例,阳性率17.35%,对照组阳性76例,阳性率12.58%,2组比较差异有统计学意义(χ2=5.324,P=0.021);乙型肝炎表面抗体阳性率DM2组(59.52%)低于对照组(68.21%),差异有统计学意义(χ2=9.753,P=0.002);2组乙型肝炎e抗原、乙型肝炎e抗体阳性率比较差异无统计学意义(P=0.556,P=0.210);乙型肝炎核心抗体阳性率DM2组(51.02%)高于对照组(44.37%),差异有统计学意义(χ2=5.281,P=0.022)。结论糖尿病发生与HBV感染具有一定相关性。

Objective To explore the relationship between hepatitis B virus infection and type 2 diabetes mellitus. Methods A total of 588 cases of type 2 diabetes mellitus and 604 controls were detected serological markers of hepatitis B virus with ELISA to compare the positive rate of serum markers of hepatitis B virus. Results The positive rates of hepatitis B surface antigen were 17. 35% （102/588） and 12. 58% （76/604） in diabetic group and control group, which showed a significant difference between two groups（x2=5. 324, P=0. 021）. The positive rates of hepatitis B surface antibodies were 59.52% and 68.21% in diabetic group and control group, which showed a significant difference between two groups（x2=9. 753, P=0. 002）. There were no significant differences in hepatitis B e antigen or hepatitis B e antibody between two groups （P=0. 556, 0. 210）. The positive rates of hepatitis B core antibody were 51. 02% and 44. 73% in diabetic group and control group, which showed a significant difference between two groups（x2= 5. 281, P = 0. 022）. Conclusion Diabetes mellitus is correlated with hepatitis B virus infection.