蕈样肉芽肿组织中psoriasin的表达及意义

Expression of psoriasin in mycosis fungoides and its significance

目的研究psoriasin(S100A7)在蕈样肉芽肿中的表达及作用机制。方法用免疫组化方法检测正常皮肤组织及蕈样肉芽肿皮损中psoriasin蛋白的表达变化。结果 psoriasin蛋白不表达于正常皮肤组织;在21例蕈样肉芽肿中,可见psoriasin蛋白表达于角质层及棘层,而不表达于基底层,阳性率为90.5%。在蕈样肉芽肿中,psoriasin的表达明显低于正常皮肤组织(P<0.001)。结论 psoriasin可能通过趋化CD4+T细胞在蕈样肉芽肿的发病中起作用。

Objective To investigate the role of psoriasin in mycosis fungoides.Methods Psoriasin protein expressions in normal skin tissues and mycosis fungoides tissues were detected by immunohistochemistry.Results Psoriasin protein was not expressed in normal skin tissues.In 21 mycosis fungoides tissue specimens,psoriasin was expressed in the stratum corneum and stratum spinosum but not in the stratum basale,with a positivity rate of 90.5% in these specimens.Psoriasin expression was significantly higher in mycosis fungoidesa tissues than in normal tissues（P 0.001）.Conclusion Psoriasin may play a role in the pathogenesis of mycosis fungoides by chemotaxis of CD4 ＋ T lymphocytes.