CY211在胰腺癌早期诊断及转移分化中的应用价值

Application of CY211 in diagnosis of early metastasis and differentiation of pancreatic cancer

目的探索CY211在胰腺癌早期诊断及其转移分化中的应用价值。方法收集病理确诊的胰腺癌病人血清,分别按淋巴结阴性阳性和分化程度各分为两组进行血清CY211、CA199、LPS(脂肪酶)、AMY(淀粉酶)检测并与健康对照组比较。结果 CY211、CA199、LPS联合诊断胰腺癌ROC达到96.7%,灵敏度达到92%;淋巴结(+)组CY211血清浓度高于淋巴结(-)组(P<0.01),低分化组高于高分化组(P<0.01)。结论 CY211能辅助诊断胰腺癌,联合CA199、LPS可提高诊断灵敏度,对胰腺癌转移分化鉴定有一定作用。

Objective To study the application of CY211 in diagnosis of early metastasis and differentiation of pancreatic cancer.Methods Serum was collected from patients with pancreatic cancer.Patients were divided into two groups based on positive and negative lymph nodes and their differentiation level.Their CY211,CA199,lipase（LPS） and amylase（AMY） levels were measured and compared with those in controls.Results The ROC area of pancreatic cancer was 96.7% when combined detection of CY211,CA199 and LPS was used in its diagnosis.The sensitivity of combined detection of CY211,CA199 and LPS was 92%.The serum CY211 level was higher in lymph node positive group and poor differentiation group than in lymph node negative group and high differentiation group（P〈0.01）.Conclusion CY211 can help the diagnosis of pancreatic cancer and combined detection of CY211,CA199 and LPS can increase the sensitivity of pancreatic cancer diagnosis and plays a role in identification of metastasis and differentiation of pancreatic cancer.