静脉滴注加替沙星566例不良反应分析及对策

Analysis and countermeasures of 566 cases of adverse drug reactions of intravenous gatifloxacin

目的分析静脉滴注加替沙星不良反应的临床表现,为临床安全用药提供指导。方法对我院2009年6月～2010年9月发生的566例静脉滴注加替沙星导致的药品不良反应(adverse drug reaction,ADR)报告进行统计分析。结果 566例ADR报告中,年龄16～89岁,平均年龄37.51岁。男247例,女319例,男女比例1∶1.29,男性ADR发生率略低于女性。ADR主要表现为皮肤症状(34.04%)、胃肠道症状(21.13%)以及静脉给药局部症状(17.14%)。结论我院注射用加替沙星存在超适应证、滴注速度偏快等现象,绝大多数ADR可通过合理用药予以避免,应加大对注射用加替沙星合理用药的干预力度。

Objective To analyze the clinical manifestations of adverse drug reactions（ADR） of intravenous gatifloxacin,to provide guidance for clinical drug safety measures.Methods The 566 cases of ADR of gatifloxacin intravenous infusion that occurred in a hospital from June 2009 to September 2010 were reported and analyzed.Results Among the 566 cases of ADR reports,the age of patients ranged from 16 to 89 years,with an average age of 37.51 years;247 cases were male,319 female,and the male to female ratio was 1∶1.29,the incidence of male ADR was slightly lower than female.The most common ADRs were skin symptoms（34.04%）,gastrointestinal symptoms（21.13%） and local symptoms at the sites of intravenous administration（17.14%）.Conclusion： Problems existed in the intravenous administration of gatifloxacin in the hospital were mainly super indications,high infusion rates.The majority of ADRs can be avoided through better efforts of the reinforcement of rational use of drugs.