摘要
目的 探讨血清胃蛋白酶原(PG)含量和幽门螺杆菌(Hp)感染与反流性食管炎(RE)的关系.方法 经胃镜检查诊断RE患者31例,其中0级10例,Ⅰ级8例,Ⅱ级7例,Ⅲ级6例,正常对照组20例.用乳胶增强免疫比浊法测定血清中的PGⅠ和PGⅡ含量,同时计算出PGⅠ/PGⅡ比值(PGR).另外采用酶联免疫法分析血清抗幽门螺杆菌IgG抗体.结果 RE分级越高组的患者PGⅠ的含量越低(依次为112.2±14.4 ng/ml;88.2±9.8 ng/ml;76.1±10.2 ng/ml;62.4±13.5 ng/ml);RE各分级组间PGⅠ含量和PGR值差异均有统计学显著性意义(F=128.71,P〈0.01;F=88.45,P〈0.01),PGⅡ含量(依次为45.1±5.1 ng/ml;46.3±4.2 ng/ml;47.5±4.4 ng/ml;49.7±5.7 ng/ml)相比差异无统计学显著性意义(F=1.72,P〉0.05);血清抗Hp抗体阳性的RE患者血清PGⅠ含量(78.2±10.4 ng/ml)及PGR(55.2±11.6 ng/ml)比血清抗Hp抗体阴性的RE患者低,两组相比均差异有统计学显著性意义(t=23.14,P〈0.01;t=48.26,P〈0.01).结论 PG含量变化和Hp感染与RE病变程度有关,联合检测PG和Hp对诊疗RE具有积极的意义.
Objective To investigate the relationship between serum pepsinogenlevels as well as anti-Hp IgG with reflux esophagitis. Methods 31 cases were selected in the study,Reflux Esophagitis were diagnosed by endoscopy including 10 cases of 0 grade,8 cases of Ⅰ grade,7 cases of Ⅱ grade,6 cases of Ⅲ grade,and 20 normal subjects were measured serum pepsingen Ⅰ ,pepsinogen Ⅱ levels by lactoprene immunoturbidimetrie assay and calculate PG Ⅰ /PG Ⅱ ratio(PGR). Anti-Hp IgG were detected by ELISA assay. Results PG Ⅰ level (112.2±14.4 ng/ml;88.2±9.8 ng/ml;76.1 ± 10. 2 ng/ml; 62.4±13.5 ng/ml) were gradually deereasd from 0 grade to | grade. There were obvious differences of PG I lesel and PGR among different grade of reflux esophagitis (F=128.71,P〈0. 01;F=88.45,P〈0. 01),however on differences of PG level (45.1±5.1 ng/ml ; 46.3±4.2 ng/ml; 47.5 ± 4.4 ng/ml ; 49.7 ± 5.7 ng/ml) (F = 1.72, P〉 0. 05). Serum PG I level (78.2±10. 4 ng/ml) and PGR (55.2±11.6 ng/ml) in positive anti-Hp IgG groups were significantly lower than that in negative anti-Hp IgG groups. There was obvious differences between two group (t=23.14,P〈0. 01 and t=48.26,P〈 0. 01). Conclusion The combined detection of PG level and anti-ttp IgG were valuable for diagnosis of reflux esophagitis and its pathological changes.
出处
《现代检验医学杂志》
CAS
2011年第5期29-31,共3页
Journal of Modern Laboratory Medicine