Ca-125用于鉴别肺结核与其他肺部感染的研究

Ca-125 Helps to Differentiate Pulmonary Tuberculosis form Other Pulmonary Infections

Ca-125在许多恶性疾病中会造成其血清水平增高,但肺部及肺外结核也会使其升高。对一段时间内诊断为肺结核的患者的血清进行Ca-125测定。将结果与非结核肺部感染患者的结果相比较。结果在收集到的99名患者中,有45名肺结核患者和54名其他呼吸系统感染患者。结核组Ca-125均值为105.3 IU/mL(SD±135.6)。对照组中均值为27.1 IU/mL(SD±19.7)。肺结核最佳临界值32.5 IU/mL(敏感度68.6%,特异性77.8%)。当Ca-125高于32.5 IU/mL时,肺结核是唯一相关因素。在20名结核患者中进行了Ca-125监测,显示在2个月的治疗过程中持续下降。说明肺结核患者的Ca-125会升高,通过治疗可以恢复正常范围。对结核痰涂片为阴性的患者可检测Ca-125进行鉴别诊断。

Ca-125 serum levels may be increased in malignant diseases, like ovarian cancer but also in other medical conditions, such as pulmonary and extrapulmonary tuberculosis. From Jan-2010 to Aug-2010 a retrospective study analyzing Ca-125 levels in serum samples from patients with a diagnosis of pulmonary TB was performed. These results were compared with other samples obtained from patients with non-TB pulmonary infections. It is resulted that 99 patients were included in the study, 45 with pulmonary TB and 54 with other respiratory infections. In patients with TB, the mean Ca-125 value was 105.3 IU/mL （SD： ± 135.6）. In the control group, mean value was 27.1 IU/mL （ SD ：± 19.7 ）. The optimal cut-off for pulmonary tuberculosis was 32.5 IU/mL （ sensitivity ： 68.6% , specificity：77.8% ）. Pulmonary TB was the only factor associated with a Ca-125 level 〉32.5. In 20 patients with TB, Ca-125 levels were available 2 months after starting TB therapy and a decrease during treatment was shown. It is conclused that Ca-125 values increase in patients with pulmonary TB and decline to normal values during treatment. Determination of Ca-125 may be usedin patients with a negative sputum AFB stain.