摘要
Liver transplantation is considered as the most effective treatment for end-stage liver disease.However,serious complications still exist,particularly in two aspects:ischemia and subsequent reperfusion of the liver,causing postoperative hepatic dysfunction and even failure;and acute and chronic graft rejections,affecting the allograft survival.Heme oxygenase(HO),a stressresponse protein,is believed to exert a protective function on both the development of ischemia-reperfusion injury(IRI) and graft rejection.In this review of current researches on allograft protection,we focused on the HO-1.We conjecture that HO-1 may link these two main factors affecting the prognosis of liver transplantations.In this review,the following aspects were emphasized:the basic biological functions of HO-1,itsroles in IRI and allograft rejection,as well as methods to induce HO-1 and the prospects of a therapeutic application of HO-1 in liver transplantation.
Liver transplantation is considered as the most effective treatment for end-stage liver disease. However, serious complications still exist, particularly in two aspects： ischemia and subsequent reperfusion of the liver, causing postoperative hepatic dysfunction and even failure; and acute and chronic graft rejections, affecting the allograft survival. Heme oxygenase （HO）, a stress- response protein, is believed to exert a protective func- tion on both the development of ischemia-reperfusion injury （IRI） and graft rejection. In this review of cur- rent researches on allograft protection, we focused on the HO-1. We conjecture that HO-1 may link these two main factors affecting the prognosis of liver trans-plantations. In this review, the following aspects were emphasized： the basic biological functions of HO-1, its roles in IRI and allograft rejection, as well as methods to induce HO-1 and the prospects of a therapeutic application of HO-1 in liver transplantation.
基金
Supported by The grants for Young Scientist Project,National Natural Science Foundation of China,No.30600598
"Qi Ming Star for Young Scientist"Project,Science and Technology Commission of Shanghai Municipality,No.10QH1401800
"Shu Guang Scholar"Project,Shanghai Municipal Educational Commission,No.10SG20
Research and Innovation Project of Shanghai Municipal Education Commission,Project No.09YZ103
the Key Medical Project of Science and Technology Commission of Shanghai Municipality,No.09411952500
Nano-specific Project of Science and Technology Commission of Shanghai Municipality,Project No.0952nm03800
